Prevalence of serum celiac antibody in patients with IBD in Japan

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• 作者：Chikako Watanabe (1)
  Shunsuke Komoto (1)
  Ryota Hokari (1)
  Chie Kurihara (1)
  Yoshikiyo Okada (1)
  Hideaki Hozumi (1)
  Masaaki Higashiyama (1)
  Atsushi Sakuraba (3)
  Kengo Tomita (1)
  Yoshikazu Tsuzuki (1)
  Atsushi Kawaguchi (1)
  Shigeaki Nagao (1)
  Sho Ogata (2)
  Soichiro Miura (1)
  
• 关键词：Celiac disease ; Japanese ; Inflammatory bowel diseases ; Gluten
• 刊名：Journal of Gastroenterology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：49
• 期：5
• 页码：825-834
• 全文大小：
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• 作者单位：Chikako Watanabe (1)
  Shunsuke Komoto (1)
  Ryota Hokari (1)
  Chie Kurihara (1)
  Yoshikiyo Okada (1)
  Hideaki Hozumi (1)
  Masaaki Higashiyama (1)
  Atsushi Sakuraba (3)
  Kengo Tomita (1)
  Yoshikazu Tsuzuki (1)
  Atsushi Kawaguchi (1)
  Shigeaki Nagao (1)
  Sho Ogata (2)
  Soichiro Miura (1)
  
  1. Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
  3. Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, USA
  2. Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan
  
• ISSN：1435-5922

文摘

Background Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. Methods A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In sero-positive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed. Some of the sero-positive patients started a gluten-restricted or unrestricted diet, and serological change was determined. Results The positivity of both serum antibodies was significantly higher in IBD and correlated with disease activity. However, no biopsy-defined or HLA-defined true celiac disease was found. A decrease in serum antibody titers was observed with a gluten-restricted diet. Conclusions Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations.