Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

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• 作者：Muthukaruppan Gnanadesigan ; Ali S. Hussain…
• 关键词：Optical coherence tomography ; Attenuation ; Lipid core plaque
• 刊名：The International Journal of Cardiovascular Imaging
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：5-11
• 全文大小：1028KB
• 刊物类别：Medicine
• 刊物主题：Cardiology; Imaging / Radiology; Cardiac Imaging;
• 出版者：Springer Netherlands
• ISSN：1573-0743
• 卷排序：33

文摘

Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.