Role of Nitric Oxide and Lipid Peroxidation in Pathophysiological Mechanisms of Audiogenic Seizures in GEP Rats and DBA/2 Mice
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- 作者：V. G. Bashkatova ; V. D. Mikoyan ; L. A. Malikova and K. S. Raevskii
- 关键词：nitric oxide ; audiogenic seizures ; lipid peroxidation ; glutamate neurotoxicity
- 刊名：Bulletin of Experimental Biology and Medicine
- 出版年：2003
- 出版时间：2003
- 年：2003
- 卷：136
- 期：1
- 页码：7-10
- 全文大小：354 KB
文摘
We evaluated the role of nitric oxide and lipid peroxidation in the pathophysiological mechanisms of seizures in genetically epilepsy prone (GEP) rats and DBA/2 mice with genetically determined audiogenic epilepsy. In rats and mice acoustic stimulation led to locomotor activation followed by clonic-tonic seizures. The contents of nitric oxide and lipid peroxidation products at the peak of seizures markedly surpassed the control level.