Prepulse inhibition of change-related P50m no correlation with P50m gating

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• 作者：Koji Inui ; Aki Tsuruhara ; Kei Nakagawa ; Makoto Nishihara ; Minori Kodaira…
• 关键词：Auditory evoked magnetic fields ; Prepulse inhibition ; Sensory gating
• 刊名：SpringerPlus
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：2
• 期：1
• 全文大小：570KB
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• 作者单位：Koji Inui (9)
  Aki Tsuruhara (9)
  Kei Nakagawa (9)
  Makoto Nishihara (10)
  Minori Kodaira (9)
  Eishi Motomura (11)
  Ryusuke Kakigi (9)
  
  9. Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan
  10. Multidisciplinary Pain Center, Aichi Medical University, Aichi, 480-1195, Japan
  11. Department of Psychiatry, Mie University Graduate School of Medicine, Tsu, 514-8507, Japan
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

Both prepulse inhibition (PPI) of the startle response and P50 sensory gating are important tools to investigate the inhibitory mechanisms of sensory processing. However, previous studies found no or a weak association between these two measures, which may have been due to the different indexes used. We examined the relationship between P50 sensory gating and P50 PPI. P50m sensory gating and PPI of Change-related P50m were assessed in 14 subjects using magnetoencephalography. Concerning P50m sensory gating, the amplitudes of the response to the second click relative to that to the first one were reduced by 43 and 47% for the left and right hemisphere, respectively. Change-related P50m was evoked by an abrupt sound pressure increase by 10 dB in a continuous click train of 70 dB. When this test stimulus was preceded by a click (prepulse) with a weaker sound pressure increase (5 dB) at a prepulse-test interval of 30, 60, or 90 ms, Change-P50m was suppressed by 33鈥墌鈥?5% while the prepulse itself elicited no or very weak P50m responses. Although the amplitude of the P50m response to the first click and the amplitude of the Change-P50m test alone response were positively correlated (r鈥?鈥?.6), the degree of the inhibition of the two measures was not (r鈥?鈥?0.06鈥墌鈥?.14). The neural origin was estimated to be located in the supratemporal plane around the superior temporal gyrus or Heschl鈥檚 gyrus and did not differ between P50m and Change-P50m. The present results suggest that P50m and Change-P50m are generated by a similar group of neurons in the auditory cortex, while the mechanisms of P50m sensory gating and Change-P50m PPI are different. Keywords Auditory evoked magnetic fields Prepulse inhibition Sensory gating