Aurora kinase targeting in lung cancer reduces KRAS-induced transformation

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• 作者：Edmilson Ozorio dos Santos ; Tatiana Correa Carneiro-Lobo…
• 刊名：Molecular Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：2,167 KB
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• 作者单位：Edmilson Ozorio dos Santos (1)
  Tatiana Correa Carneiro-Lobo (1)
  Mateus Nobrega Aoki (1)
  Elena Levantini (2) (3)
  Daniela Sanchez Bassères (1)
  
  1. Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, SP, Brazil
  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
  3. Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy
  
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1476-4598

文摘

Background Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification of KRAS targets that impinge on the oncogenic phenotype is warranted. Based on published studies showing that mitotic kinases Aurora A (AURKA) and B (AURKB) cooperate with oncogenic RAS to promote malignant transformation and that AURKA phosphorylates RAS effector pathway components, the aim of this study was to investigate whether AURKA and AURKB are KRAS targets in lung cancer and whether targeting these kinases might be therapeutically beneficial.