Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors

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• 作者：D. A. Lomov ; S. N. Lyashchuk ; M. G. Abramyants
• 刊名：Russian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：52
• 期：12
• 页码：1822-1829
• 全文大小：
• 刊物主题：Organic Chemistry;
• 出版者：Pleiades Publishing
• ISSN：1608-3393
• 卷排序：52

文摘

Computer simulation at the PM7 level of theory of the structures of imidazo[4,5-c]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of new compounds of the selected imidazo[4,5-c]pyridine series, for which the highest inhibitory activity against AURKA was predicted, were synthesized in high yields for further biological testing.