Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases

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• 作者：J. M. M. Howson (1) Joanna.Howson@cimr.cam.ac.uk
  S. Krause (2)
  H. Stevens (1)
  D. J. Smyth (1)
  J. M. Wenzlau (3)
  E. Bonifacio (4)
  J. Hutton (3)
  A. G. Ziegler (25)
  J. A. Todd (1) John.Todd@cimr.cam.ac.uk
  P. Achenbach (25)
• 关键词：Autoantibody – ; FCRL3 – ; HLA – ; MHC – ; SLC30A8 – ; Type 1 diabetes – ; Zinc transporter 8
• 刊名：Diabetologia
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：55
• 期：7
• 页码：1978-1984
• 全文大小：189.6 KB
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• 作者单位：1. Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke鈥檚 Hospital, Hills Road, Cambridge, CB2 0XY UK2. Forschergruppe Diabetes, Munich University of Technology, Munich, Germany3. Barbara Davis Diabetes Centre, University of Colorado, Denver, CO, USA4. Centre for Regenerative Therapies, Dresden University of Technology, Dresden, Germany5. Institute of Diabetes Research, Helmholtz Centre Munich, Neuherberg, Germany
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A.