Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway
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- 作者：Zhai Ertao ; Chen Jianhui ; Chen Chuangqi…
- 关键词：Gastric cancer ; Autocrine ; Sonic hedgehog ; Proliferation ; Prognosis
- 刊名：Journal of Experimental & Clinical Cancer Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：35
- 期：1
- 全文大小：3,191 KB
- 刊物主题：Oncology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-9966
文摘
Background Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote cell proliferation and epithelial-to-mesenchymal transition. However, the autocrine SHH pathway has not been described in gastric cancer. The aim of this study was to explore molecular mechanisms underlying autocrine SHH signaling in gastric cancer cells.