Unmanipulated native fat exposed to high-energy diet, but not autologous grafted fat by itself, may lead to overexpression of Ki67 and PAI-1

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• 作者：Francisco Claro Jr. ; Joseane Morari ; Luciana R Moreira ; Lu铆s O Z Sarian…
• 关键词：Fat grafting ; Breast cancer ; Lipofilling ; PAI ; 1 ; Ki67 ; CD68
• 刊名：SpringerPlus
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：1
• 全文大小：1204KB
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• 作者单位：Francisco Claro Jr. (1) (2)
  Joseane Morari (3)
  Luciana R Moreira (4)
  Lu铆s O Z Sarian (1)
  Glauce A Pinto (4)
  Licio A Velloso (3)
  Aar茫o M Pinto-Neto (1)
  
  1. Department of Gynecology and Obstetrics at School of Medical Sciences, State University of Campinas (UNICAMP), R. Alexander Fleming, 101, Campinas, SP, 13083-881, Brazil
  2. Santa Cruz Plastic Surgery Institute (ICPSC), S茫o Paulo, SP, Brazil
  3. Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, SP, Brazil
  4. Laboratory of Specialized Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

Background Although its unclear oncological risk, which led to more than 20 years of prohibition of its use, fat grafting to the breast is widely used nowadays even for aesthetic purposes. Thus, we proposed an experimental model in rats to analyze the inflammatory activity, cellular proliferation and levels of Plasminogen Activator Inhibitor (PAI-1) in grafted fat, and in native fat exposed to high-energy diet in order to study the oncological potential of fat tissue.