Autonomic Nervous System Dysregulation in Pediatric Hypertension

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• 作者：Janusz Feber (1)
  Marcel Ruzicka (2)
  Pavel Geier (1)
  Mieczyslaw Litwin (3)
  
• 关键词：Arterial hypertension ; Autonomous nervous system ; Sympathetic nervous system ; Children
• 刊名：Current Hypertension Reports
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：16
• 期：5
• 全文大小：236 KB
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• 作者单位：Janusz Feber (1)
  Marcel Ruzicka (2)
  Pavel Geier (1)
  Mieczyslaw Litwin (3)
  
  1. Division of Nephrology, Department of Pediatrics, Children鈥檚 Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8聽L1, Canada
  2. Division of Nephrology, The Ottawa Hospital, University of Ottawa, 1967 Riverside Dr. Suite 5-21, Ottawa, Ontario, K1H 7聽W9, Canada
  3. Department of Nephrology and Hypertension, Children鈥檚 Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland
  
• ISSN：1534-3111

文摘

Historically, primary hypertension (HTN) has been prevalent typically in adults. Recent data however, suggests an increasing number of children diagnosed with primary HTN, mainly in the setting of obesity. One of the factors considered in the etiology of HTN is the autonomous nervous system, namely its dysregulation. In the past, the sympathetic nervous system (SNS) was regarded as a system engaged mostly in buffering major acute changes in blood pressure (BP), in response to physical and emotional stressors. Recent evidence suggests that the SNS plays a much broader role in the regulation of BP, including the development and maintenance of sustained HTN by a chronically elevated central sympathetic tone in adults and children with central/visceral obesity. Consequently, attempts have been made to reduce the SNS hyperactivity, in order to intervene early in the course of the disease and prevent HTN-related complications later in life.