Neurohumoral changes in rats of different age groups on the background of injection of cryopreserved cord blood nucleated cells
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- 作者：Yu. V. Martynova ; V. G. Babiychuk ; L. A. Sirotenko ; N. G. Malova…
- 关键词：aging ; cord blood nucleated cells ; heart rate variability ; autonomic nervous system ; hormonal regulation
- 刊名：Advances in Gerontology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：6
- 期：4
- 页码：304-310
- 全文大小：
- 刊物主题：Geriatrics/Gerontology;
- 出版者：Pleiades Publishing
- ISSN：2079-0589
- 卷排序：6
文摘
The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also noticed an increase of the thyroid hormone concentration in the blood serum of the old rats. The concentration decreased with age. In addition, it was shown that the injection of UCB NCs during the animal’s life cycle (every 6 months) made it possible to maintain a functional state of the autonomous nervous system at a “young” physiological level.