Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
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- 作者：Anna Klimaszewska-Wisniewska ; Marta Halas-Wisniewska…
- 关键词：Fisetin ; Paclitaxel ; Combination therapy ; Lung cancer ; Mitotic catastrophe ; Autophagy
- 刊名：Cancer Cell International
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：9,923 KB
- 刊物主题：Cancer Research; Cell Biology;
- 出版者：BioMed Central
- ISSN：1475-2867
文摘
Background The use of the dietary polyphenols as chemosensitizing agents to enhance the efficacy of conventional cytostatic drugs has recently gained the attention of scientists and clinicians as a plausible approach for overcoming the limitations of chemotherapy (e.g. drug resistance and cytotoxicity). The aim of this study was to investigate whether a naturally occurring diet-based flavonoid, fisetin, at physiologically attainable concentrations, could act synergistically with clinically achievable doses of paclitaxel to produce growth inhibitory and/or pro-death effects on A549 non-small cell lung cancer cells, and if it does, what mechanisms might be involved.