Phycocyanin moderates aging and proteotoxicity in Caenorhabditis elegans

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• 作者：Niraj K. Singh ; Ravi R. Sonani ; Anjali Awasthi…
• 关键词：Phycocyanin ; Caenorhabditis elegans ; Antioxidant ; Anti ; aging ; Huntington disease
• 刊名：Journal of Applied Phycology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：28
• 期：4
• 页码：2407-2417
• 全文大小：975 KB
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• 作者单位：Niraj K. Singh (1) (2)
  Ravi R. Sonani (1)
  Anjali Awasthi (3) (4)
  Birendra Prasad (5)
  Anjali R. Patel (2)
  Jitendra Kumar (6) (7)
  Datta Madamwar (1)
  
  1. BRD School of Biosciences, Sardar Patel University, Vadtal Road, Satellite Campus, Post Box No- 39, Vallabh Vidyanagar, 388 120, Gujarat, India
  2. Department of Biotechnology, Shri A. N. Patel PG Institute, Anand, 388 001, Gujarat, India
  3. Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, 333 031, Rajasthan, India
  4. Department of Biology, School of Engineering, Presidency University, Bengaluru, 560089, Karnataka, India
  5. Department of Botany/Biotechnology, Patna University, Patna, 800005, Bihar, India
  6. The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA
  7. DBT-PU-IPLS Programme, Department of Botany/Biotechnology, Patna University, Patna, Bihar, 800005, India
  
• 刊物主题：Plant Sciences; Freshwater & Marine Ecology; Plant Physiology; Ecology;
• 出版者：Springer Netherlands
• ISSN：1573-5176
• 卷排序：28

文摘

Phycocyanin (PC, isolated from Leptolyngbya sp. N62DM) was tested for its anti-aging and proteostasis-suppressive potential by using the Caenorhabditis elegans model. PC (100 μg mL−1) treatment to wild-type (N2) C. elegans extended the mean life span from 14.8 ± 0.5 to 19.1 ± 0.7 days. PC-treated aged worms showed better pharyngeal pumping and locomotion rate compared to similar age untreated animals. PC treatment also enhanced tolerance under thermo- and oxidative-stress in N2 C. elegans. Insulin/IGF-1 signalling (IIS) pathway has been reported as the major regulator of life span in C. elegans. We checked the involvement of insulin/IGF-1 signalling (IIS) pathway in PC-mediated life span extension. PC treatment prolonged the life span in mutants of both upstream (daf-2 and age-1) and downstream (daf-16) regulators of IIS pathway. Results thus indicated that PC-mediated life span expansion is independent from DAF-2–AGE-1–DAF-16 signalling pathway. Furthermore, PC curtailed the polyQ aggregation mediated proteotoxicity in C. elegans AM141 Huntington disease model under stressed (paraquat stress) as well as normal conditions. In conclusion, this report recognizes the in vivo antioxidant activity of PC in C. elegans and illustrates its potential to be used as a tonic against aging and age associated detrimental changes. Keywords Phycocyanin Caenorhabditis elegans Antioxidant Anti-aging Huntington disease