Molecular classification of tissue from a transformed non-Hogkin’s lymphoma case with unexpected long-time remission

详细信息    查看全文

• 作者：Julie Støve Bødker ; Marianne Tang Severinsen…
• 关键词：Transformed lymphoma ; Long ; time remission ; Molecular classification ; Rituximab palliation ; Drug resistance prediction
• 刊名：Experimental Hematology & Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：6
• 期：1
• 全文大小：1245KB
• 刊物主题：Hematology; Oncology;
• 出版者：BioMed Central
• ISSN：2162-3619
• 卷排序：6

文摘

BackgroundThe concept of precision medicine in cancer includes individual molecular studies to predict clinical outcomes. In the present N = 1 case we retrospectively have analysed lymphoma tissue by exome sequencing and global gene expression in a patient with unexpected long-term remission following relaps. The goals were to phenotype the diagnostic and relapsed lymphoma tissue and evaluate its pattern. Furthermore, to identify mutations available for targeted therapy and expression of genes to predict specific drug effects by resistance gene signatures (REGS) for R-CHOP as described at http://www.hemaclass.org. We expected that such a study could generate therapeutic information and a frame for future individual evaluation of molecular resistance detected at clinical relapse.