Engineering Myocardial Tissue Patches with Hierarchical Structure–Function

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• 作者：Erin G. Roberts ; Elaine L. Lee ; Daniel Backman…
• 关键词：Cellular sheets ; Cardiac regeneration ; Computational modeling ; Biomechanical properties
• 刊名：Annals of Biomedical Engineering
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：43
• 期：3
• 页码：762-773
• 全文大小：1,142 KB
• 参考文献：1. Adamo, L, García-Carde?a, G (2011) Directed stem cell differentiation by fluid mechanical forces. Antioxid. Redox Signal. 15: pp. 1463-1473 CrossRef
  2. Adamo, L, Naveiras, O, Wenzel, PL, McKinney-Freeman, S, Mack, PJ, Gracia-Sancho, J, Suchy-Dicey, A, Yoshimoto, M, Lensch, MW, Yoder, MC (2009) Biomechanical forces promote embryonic haematopoiesis. Nature 459: pp. 1131-1135 CrossRef
  3. Chen, Q, Bismarck, A, Hansen, U, Junaid, S, Tran, MQ, Harding, SE, Ali, NN, Boccaccini, AR (2008) Characterisation of a soft elastomer poly (glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials 29: pp. 47-57 CrossRef
  Cleveland Clinic Heart Book. Disney Press, New York
  4. Cormier, JT, Nieden, NIZ, Rancourt, DE, Kallos, MS (2006) Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors. Tissue Eng. 12: pp. 3233-3245 CrossRef
  5. Damjanov, I (2004) From stem cells to germ cell tumors and back. Verh. Dtsch. Ges. Pathol. 88: pp. 39-44
  6. Denker, HW (2006) Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources. J. Med. Ethics 32: pp. 665-671 CrossRef
  7. Driessen, NJ, Cox, MA, Bouten, CV, Baaijens, FP (2008) Remodelling of the angular collagen fiber distribution in cardiovascular tissues. Biomech. Model. Mechanobiol. 7: pp. 93-103 CrossRef
  8. Ebrahimkhani, MR, Young, CL, Lauffenburger, DA, Griffith, LG, Borenstein, JT (2014) Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discov., Today CrossRef
  9. Elloumi-Hannachi, I, Yamato, M, Okano, T (2010) Cell sheet engineering: a unique nanotechnology for scaffold-free tissue reconstruction with clinical applications in regenerative medicine. J. Intern. Med. 267: pp. 54-70 CrossRef
  10. Fok, EY, Zandstra, PW (2005) Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation. Stem Cells 23: pp. 1333-1342 CrossRef
  11. Freire, AG, Nascimento, DS, Forte, G, Valente, M, Resende, TP, Pagliari, S, Abreu, C, Carvalho, I, Nardo, PD, Pinto-do-ó, P (2013) Stable phenotype and function of immortalized Lin?Sca-1 cardiac progenitor cells in long-term culture: a step closer to standardization. Stem Cells Dev. 23: pp. 1012-1026 CrossRef
  12. Gasser, TC, Ogden, RW, Holzapfel, GA (2006) Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. J. R. Soc. Interface 3: pp. 15-35 CrossRef
  13. Gerecht-Nir, S, Osenberg, S, Nevo, O, Ziskind, A, Coleman, R, Itskovitz-Eldor, J (2004) Vascular development in early human embryos and in teratomas derived from human embryonic stem cells. Biol. Reprod. 71: pp. 2029-2036 CrossRef
  14. Gerecht-Nir, S, Ziskind, A, Cohen, S, Itskovitz-Eldor, J (2003) Human embryonic stem cells as an in vitro model for human vascular development and the induction of vascular differentiation. Lab. Investig. 83: pp. 1811-1820 CrossRef
  15. Geuss, LR, Suggs, LJ (2013) Making cardiomyocytes: how mechanical stimulation can influence differentiation of pluripotent stem cells. Biotechnol. Prog. 29: pp. 1089-1096 CrossRef
  16. Go, AS, Mozaffarian, D, Roger, VL, Benjamin, EJ,
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

Complex hierarchical organization is a hallmark of tissues and their subsequent integration into organs. A major challenge in tissue engineering is to generate arrays of cells with defined structural organization that display appropriate functional properties. Given what is known about cellular responses to physiochemical cues from the surrounding environment, we can build tissue structures that mimic these microenvironments and validate these platforms using both experimental and computational approaches. Tissue generation encompasses many methods and tissue types, but here we review layering cell sheets to create scaffold-less myocardial patches. We discuss surgical criteria that can drive the design of myocardial cell sheets and the methods used to fabricate, mechanically condition, and functionally test them. We also focus on how computational and experimental approaches could be integrated to optimize tissue mechanical properties by using measurements of biomechanical properties and tissue anisotropy to create predictive computational models. Tissue anisotropy and dynamic mechanical stimuli affect cell phenotype in terms of protein expression and secretion, which in turn, leads to compositional and structural changes that ultimately impact tissue function. Therefore, a combinatorial approach of design, fabrication, testing, and modeling can be carried out iteratively to optimize engineered tissue function.