Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals

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• 作者：Rebecca C. Price ; Nicolas V. Christou ; Steven B. Backman ; Laura Stone…
• 关键词：Beta ; endorphin ; Opioid ; Obesity ; Depression ; Anxiety ; Naltrexone
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：233
• 期：23-24
• 页码：3869-3879
• 全文大小：641 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072
• 卷排序：233

文摘

RationaleEndogenous opioids inhibit nociceptive processing and promote the experience of pleasure. It has been proposed that pain and pleasure lie at opposite ends of an affective spectrum, but the relationship between pain and pleasure and the role of opioids in mediating this relationship has not been tested.