Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria
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- 作者：Laura F. Fielden ; Yilin Kang ; Hayley J. Newton…
- 关键词：Mitochondria ; Intravacuolar bacterial pathogens ; Protein trafficking ; Bacterial effector proteins ; Mitochondrial function
- 刊名：Cell and Tissue Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：367
- 期：1
- 页码：141-154
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Human Genetics; Proteomics; Molecular Medicine;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0878
- 卷排序：367
文摘
Manipulation of host cell function by bacterial pathogens is paramount for successful invasion and creation of a niche conducive to bacterial replication. Mitochondria play a role in many important cellular processes including energy production, cellular calcium homeostasis, lipid metabolism, haeme biosynthesis, immune signalling and apoptosis. The sophisticated integration of host cell processes by the mitochondrion have seen it emerge as a key target during bacterial infection of human host cells. This review highlights the targeting and interaction of this dynamic organelle by intravacuolar bacterial pathogens and the way that the modulation of mitochondrial function might contribute to pathogenesis.