Differential regulation of riboflavin supply genes in Vibrio cholerae
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- 作者：Ignacio Sepúlveda Cisternas ; Alexia Torres ; Andrés Fuentes Flores…
- 关键词：Vibrio cholerae ; Riboflavin ; Transporter ; Biosynthesis ; Gene regulation
- 刊名：Gut Pathogens
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1383KB
- 刊物主题：Gastroenterology; Medical Microbiology; Parasitology;
- 出版者：BioMed Central
- ISSN：1757-4749
- 卷排序：9
文摘
BackgroundRiboflavin is the precursor of important redox cofactors such as flavin mononucleotide (FMN) and flavin adenine dinucleotide, required for several biological processes. Vibrio cholerae, a pathogenic bacterium responsible for the cholera disease, possesses the ability to biosynthesize de novo as well as to uptake riboflavin through the riboflavin biosynthetic pathway (RBP) and the RibN importer, respectively. The intra-organism relationship between riboflavin biosynthesis and uptake functions has not been studied.