A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia

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• 作者：Marie Lemper ; Sofie De Groef ; Geert Stangé ; Luc Baeyens ; Harry Heimberg
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：59
• 期：9
• 页码：1948-1958
• 全文大小：1,351 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428
• 卷排序：59

文摘

Aims/hypothesisWhen the beta cell mass or function declines beyond a critical point, hyperglycaemia arises. Little is known about the potential pathways involved in beta cell rescue. As two cytokines, epidermal growth factor (EGF) and ciliary neurotrophic factor (CNTF), restored a functional beta cell mass in mice with long-term hyperglycaemia by reprogramming acinar cells that transiently expressed neurogenin 3 (NGN3), the current study assesses the effect of these cytokines on the functional beta cell mass after an acute chemical toxic insult.