Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737

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• 作者：Jens Mani ; Patrick Antonietti ; Stefanie Rakel ; Roman Blaheta…
• 关键词：BAG3 ; ATG5 ; ABT ; 737 ; Bladder cancer
• 刊名：World Journal of Urology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：34
• 期：2
• 页码：197-205
• 全文大小：1,058 KB
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• 作者单位：Jens Mani (1)
  Patrick Antonietti (2)
  Stefanie Rakel (2)
  Roman Blaheta (1)
  Georg Bartsch (1)
  Axel Haferkamp (1)
  Donat Kögel (2)
  
  1. Department of Urology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany
  2. Experimental Neurosurgery, Neuroscience Center, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Urology and Andrology
  Nephrology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8726

文摘

Purpose BAG3 is overexpressed in several malignancies and mediates a non-canonical, selective form of (macro)autophagy. By stabilizing pro-survival Bcl-2 proteins in complex with HSP70, BAG3 can also exert an apoptosis-antagonizing function. ABT-737 is a high affinity Bcl-2 inhibitor that fails to target Mcl-1. This failure may confer resistance in various cancers.