Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation
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- 作者：Ahalya Balachandran ; Raymond Wong ; Peter Stoilov ; Sandy Pan…
- 关键词：HIV ; 1 ; RNA processing ; Tat ; Rev ; Small molecule inhibitors
- 刊名：Retrovirology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：5202KB
- 刊物主题：Virology; Infectious Diseases; Cancer Research; Vaccine; Antibodies; Protein Structure;
- 出版者：BioMed Central
- ISSN：1742-4690
- 卷排序：14
文摘
BackgroundHIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of specific HIV-1 RNAs and the levels of Tat and Rev proteins.