Caveolin proteins: a molecular insight into disease
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- 作者：Hongli Yin ; Tianyi Liu ; Ying Zhang ; Baofeng Yang
- 关键词：caveolin ; caveolae ; microRNA ; disease ; signaling pathway ; heart ; tumor
- 刊名：Frontiers of Medicine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：10
- 期：4
- 页码：397-404
- 全文大小：
- 刊物主题：Medicine/Public Health, general;
- 出版者：Higher Education Press
- ISSN：2095-0225
- 卷排序：10
文摘
Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent years, many researchers have found that both caveolins and caveolae play a role in the development of various human diseases, including coronary heart disease, hypertension, and nervous system disorders. The specific mechanisms by which caveolins induce diseases have been a topic of interest. However, a number of detailed molecular mechanisms remain poorly understood. This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular mechanisms of caveolins in disease networks.