Structural DNA Nanotechnology: Molecular Construction and Computation

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• 作者：Ruojie Sha ; Xiaoping Zhang ; Shiping Liao ; Pamela E. Constantinou ; Baoquan Ding ; et al.
• 关键词：Unusual DNA Motifs ; Bottom ; Up Nanoscale Construction ; DNA Sequence Design ; Nanoscale DNA Objects ; Nanorobotics ; Nanoscale Pattern Design
• 刊名：Lecture Notes in Computer Science
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：3699
• 期：1
• 页码：p.20
• 全文大小：1,819 KB
• 刊物类别：Computer Science
• 刊物主题：Artificial Intelligence and Robotics
  Computer Communication Networks
  Software Engineering
  Data Encryption
  Database Management
  Computation by Abstract Devices
  Algorithm Analysis and Problem Complexity
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1611-3349

文摘

Structural DNA nanotechnology entails the construction of objects, lattices and devices from branched DNA molecules. Branched DNA molecules open the way for the construction of a variety of N-connected motifs. These motifs can be joined by cohesive interactions to produce larger constructs in a bottom-up approach to nanoconstruction. The first objects produced by this approach were stick polyhedra and topological targets, such as knots and Borromean rings. These were followed by periodic arrays with programmable patterns. It is possible to exploit DNA structural transitions and sequence-specific binding to produce a variety of DNA nanomechanical devices, which include a bipedal walker and a machine that emulates the translational capabilities of the ribosome. Much of the promise of this methodology involves the use of DNA to scaffold other materials, such as biological macromolecules, nanoelectronic components, and polymers. These systems are designed to lead to improvements in crystallography, computation and the production of diverse and exotic materials. Branched DNA can be used to emulate Wang tiles, and it can be used to construct arbitrary irregular graphs and to address their colorability.