Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study

详细信息    查看全文

• 作者：Johanna M?kel? (1)
  Kaisa Linderborg (2)
  Harri Niinikoski (3)
  Baoru Yang (2)
  Hanna Lagstr?m (1)
  
• 关键词：Breast milk ; Breast feeding ; Fatty acids ; Infant growth ; Nutrition ; Obesity
• 刊名：European Journal of Nutrition
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：52
• 期：2
• 页码：727-735
• 全文大小：254KB
• 参考文献：1. Ludwig DS, Currie J (2010) The association between pregnancy weight gain and birthweight: a within-family comparison. Lancet 376:984-90 CrossRef
  2. Barker DJ (2004) The developmental origins of chronic adult disease. Acta Paediatr Suppl 93:26-3 CrossRef
  3. Wojcicki JM (2011) Maternal prepregnancy body mass index and initiation and duration of breastfeeding: a review of the literature. J Womens Health (Larchmt) 20:341-47 CrossRef
  4. Arenz S, Rückerl R, Koletzko B, von Kries R (2004) Breast-feeding and childhood obesity—a systematic review. Int J Obes Relat Metab Disord 28:1247-256 CrossRef
  5. Harder T, Bergmann R, Kallischnigg G, Plagemann A (2005) Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidem 162:397-03 CrossRef
  6. Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG (2005) Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics 115:1367-377 CrossRef
  7. Kramer MS, Guo T, Platt RW et al (2004) Feeding effects on growth during infancy. J Pediatr 145:600-05 CrossRef
  8. Victora CG, Morris SS, Barros FC, de Onis M, Yip R (1998) The NCHS reference and the growth of breast- and bottle-fed infants. J Nutr 128:1134-138
  9. Koletzko B, von Kries R, Closa R, Escribano J, Scaglioni S, Giovannini M et al (2009) Can infant feeding choices modulate later obesity risk? Am J Clin Nutr 89:1502S-508S CrossRef
  10. Oddy WH (2002) The impact of breastmilk on infant and child health. Breastfeed 10:5-8
  11. Szabo E, Boehm G, Beermann C, Weyermann M, Brenner H, Rothenbacher D, Decsi T (2010) Fatty acid profile comparisons in human milk sampled from the same mothers at the sixth week and the sixth month of lactation. J Pediatr Gastroenterol Nutr 50:316-20 CrossRef
  12. Del Prado M, Villalpando S, Elizondo A, Rodriguez M, Demmelmair H, Koletzko B (2001) Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. Am J Clin Nutr 74:242-47
  13. Jensen RG (1999) Lipids in human milk. Lipids 34:1243-271 CrossRef
  14. Innis SM (2007) Human milk: maternal dietary lipids and infant development. Proc Nutr Soc 66:397-04 CrossRef
  15. Nasser R, Stephen AM, Goh YK, Clandinin MT (2010) The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada. Int Breastfeed J 5:3- CrossRef
  16. Jensen CL, Maude M, Anderson RE, Heird WC (2000) Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. Am J Clin Nutr 71:292S-99S
  17. Mellies MJ, Ishikawa TT, Gartside PS, Burton K, MacGee J, Allen K et al (1979) Effects of varying maternal dietary fatty acids in lactating women and their infants. Am J Clin Nutr 32:299-03
  18. Pugo-Gunsam P, Guesnet P, Subratty AH, Rajcoomar DA, Maurage C, Couet C (1999) Fatty acid composition of white adipose tissue and breast milk of Mauritian and French mothers and erythrocyte phospholipids of their full-term breast-fed infants. Br J Nutr 82:263-71
  19. Dunstan JA, Mitoulas LR, Dixon G, Doherty DA, Hartmann PE, Simmer K, Prescott SL (2007) The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. Pediatr Res 62:689-94 CrossRef
  20. Carlson SE, Werkman SH, Tolley EA (1996) Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Am J Clin Nutr 63:687-97
  21. Ryan AS, Montalto MB, Groh-Wargo S et al (1999) Effect of DHA-containing formula on growth of preterm infants to 59?weeks postmenstrual age. Am J Hum Biol 11:457-67 CrossRef
  22. Gibson RA, Chen W, Makrides M (2001) Randomized trials with polyunsaturated fatty acid interventions in preterm and term infants: functional and clinical outcomes. Lipids 36:873-83 CrossRef
  23. Lapillonne A, Carlson SE (2001) Polyunsaturated fatty acids and infant growth. Lipids 36:901-11 CrossRef
  24. Makrides M, Gibson RA, Udell T, Ried K, International LCPUFA Investigators (2005) Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants. Am J Clin Nutr 81:1094-101
  25. Scholtens S, Wijga AH, Smit HA, Brunekreef B, de Jongste JC, Gerritsen J, Seidell JC (2009) Long-chain polyunsaturated fatty acids in breast milk and early weight gain in breast-fed infants. Br J Nutr 101:116-21 CrossRef
  26. Danielzik S, Langnase K, Mast M, Spethmann C, Muller MJ (2002) Impact of parental BMI on the manifestation of overweight 5-?year old children. Eur J Nutr 41:132-38 CrossRef
  27. Lepp?l? J, Lagstr?m H, Kaljonen A, Laitinen K (2010) Construction and evaluation of a self-contained index for assessment of diet quality. Scand J Public Health 38:794-02 CrossRef
  28. Paturi M, Tapanainen H, Reinivuo H, Pietinen P (eds) (2008) The National FINDIET 2007 Survey. B23/2008. Nutrition Unit, National Public Health Institute, Helsinki
  29. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-09
  30. ?gren JJ, Julkunen A, Penttila I (1992) Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res 33:1871-876
  31. Marin MC, Sanhurho A, Rodrigo MA, de Alaniz MJT (2005) Long-chain polyunsaturated fatty acids in breast milk in La Plata, Argentina: Relationship with maternal nutritional status. Prostaglandins Leukot Essent Fatty Acids 73:355-60 CrossRef
  32. Wojcik KY, Rechtman DJ, Lee ML, Montoya A, Medo ET (2009) Macronutrient analysis of a nationwide sample of donor breast milk. J Am Diet Assoc 109:137-40 CrossRef
  33. Ailhaud G, Massiera F, Weill P, Legrand P, Alessandri JM, Guesnet P (2006) Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog Lipid Res 45:203-36 CrossRef
  34. Powe CE, Knott CD, Conklin-Brittain N (2010) Infant sex predicts breast milk energy content. Am J Hum Biol 22:50-4 CrossRef
  35. Owen CG, Whincup PH, Kaye SJ, Martin RM, Davey Smith G, Cook DG et al (2008) Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence. Am J Clin Nutr 88:305-14
  36. Schack-Nielsen L, Michaelsen KF (2007) Advances in our understanding of the biology of human milk and its effects on the offspring. J Nutr 137:503S-10S
  37. Althuizen E, van Poppel MN, Seidell JC, van Mechelen W (2009) Correlates of absolute and excessive weight gain during pregnancy. J Womens Health (Larchmt) 18:1559-566 CrossRef
  38. Hasunen K, Ryyn?nen S (2005) Infant feeding in Finland 2005. Reports of the Ministry of Social Affairs and Health
  39. Willet W (1998) Nutritional epidemiology, 2nd edn. Oxford University Press, New York CrossRef
  
• 作者单位：Johanna M?kel? (1)
  Kaisa Linderborg (2)
  Harri Niinikoski (3)
  Baoru Yang (2)
  Hanna Lagstr?m (1)
  
  1. Turku Institute for Child and Youth Research, University of Turku, 20014, Turku, Finland
  2. Department of Biochemistry and Food Chemistry, University of Turku, 20014, Turku, Finland
  3. Department of Pediatrics, University of Turku, 20014, Turku, Finland
  
• ISSN：1436-6215

文摘

Objective We studied differences in breast milk fatty acid (FA) composition between overweight and normal weight women and the effect of FA composition on children’s cholesterol concentrations at 13?months and growth from birth to 13?months. Methods Samples were collected from lactating women (n?=?100) participating in STEPS study at infant’s age of 3?months, and FA composition was analyzed with gas chromatography. Diet of mother was studied with Index of Diet Quality at third trimester of pregnancy and with food frequency questionnaire on sampling day. The children’s weights and heights were collected from hospital records at birth and during study visits at 13?months. Results Overweight women’s breast milk compared to normal weight women’s breast milk contained higher amount of saturated FAs (46.3 vs. 43.6?%, P?=?0.012), lower amount of n-3FAs (2.2 vs. 2.7?%, P?=?0.010), lower ratio of unsaturated to saturated FAs (1.1 vs. 1.3, P?=?0.008), and higher ratio of n-6 to n-3 FAs (5.7 vs. 4.9, P?=?0.031) than those of normal weight women even after adjusting for maternal diet (P?<?0.05 for all). Normal weight women adhered more to dietary recommendations during pregnancy, whereas no differences were found in diet at sampling 3?months postpartum. The children’s weight gains correlated with saturated FAs (R?=?0.22, P?=?0.04) and the ratio of unsaturated to saturated FAs (R?=??.23, P?=?0.038) in milk; however, effects diminished after adjusting for total duration of breastfeeding. Milk FA composition was not associated with children’s cholesterol concentrations at 13?months. Conclusions Breast milk FA composition differed between overweight and normal weight women.