The placebo effect: Plugging the nostrils of unmet needs
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  • 作者:James N. Baraniuk (1)
  • 刊名:Current Allergy and Asthma Reports
  • 出版年:2009
  • 出版时间:March 2009
  • 年:2009
  • 卷:9
  • 期:2
  • 页码:149-152
  • 全文大小:220KB
  • 参考文献:1. Eccles R: Mechanisms of the placebo effect of sweet cough syrups. / Respir Physiol Neurobiol 2006, 152:340鈥?48. CrossRef
    2. Pavesi L, Subburaj S, Porter-Shaw K: Application and validation of a computerized cough acquisition system for objective monitoring of acute cough-a meta-analysis. / Chest 2001, 120:1121鈥?128. CrossRef
    3. Eccles R: The powerful placebo in cough studies. / Pulm Pharmacol Ther 2002, 15:303鈥?08. CrossRef
    4. Harrington A: / The Placebo Effect: An Interdisciplinary Approach. Cambridge, MA: Harvard University Press; 1999.
    5. Mills SY: The House of Lords report on complementary medicine: a summary. / Complement Ther Med 2001, 9:34鈥?9. CrossRef
    6. Astin JA, Harkness E, Ernst E: The efficacy of 鈥渄istant healing鈥? a systematic review of randomized trials. / Ann Intern Med 2000, 132:903鈥?10.
    7. Beecher H: The powerful placebo. / JAMA 1955, 159:1602鈥?606.
    8. Kienle G, Kiene H: Placebo effect and placebo concept: a critical methodological and conceptual analysis of reports on the magnitude of the placebo effect. / Altern Ther Health Med 1996, 2:39鈥?4.
    9. Kienle GS, Kiene H: The powerful placebo effect: fact or fiction? / J Clin Epidemiol 1997, 50:1311鈥?318. CrossRef
    10. Sauro MD, Greenberg RP: Endogenous opiates and the placebo effect. A meta-analytic review. / J Psychosom Res 2005, 58:115鈥?20. CrossRef
    11. Giesecke T, Williams DA, Harris RE, et al.: Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. / Arthritis Rheum 2003, 48:2916鈥?922. CrossRef
    12. Spector SL: The placebo effect is nothing to sneeze at. / J Allergy Clin Immunol 1992, 90:1042鈥?043. CrossRef
    13. Spector SL, Toshener D, Gay I, Rosenman E: Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis. / Clin Allergy 1982, 12:187鈥?96. CrossRef
    14. Vozeh S: Is the increasing use of evidence-based pharmacotherapy causing the renaissance of complementary medicine? / Br J Clin Pharmacol 2003, 56:292鈥?96. CrossRef
    15. Patulin Clinical Trials Committee, Medical Research Council: Clinical trial of patulin in the common cold. 1944. / Int J Epidemiol 2004, 33:243鈥?46. CrossRef
    16. Ernst E, Resch KL: Concept of true and perceived placebo effects. / BMJ 1995, 311:551鈥?53.
    17. Jain R, Mukherjee K, Singh R: Influence of sweet tasting solutions on opioid withdrawal. / Brain Res Bull 2004, 64:319鈥?22. CrossRef
    18. Raphael G, Raphael MH, Kaliner M: Gustatory rhinitis: a syndrome of food-induced rhinorrhea. / J Allergy Clin Immunol 1989, 83:110鈥?15. CrossRef
    19. Lee PC, Jawad MS, Hull JD, et al.: The antitussive effect of placebo treatment on cough associated with upper respiratory infection. / Psychosom Med 2005, 67:314鈥?17. CrossRef
    20. Evans D: / Placebo. The Belief Effect. London: Harper Collins; 2003.
    21. Benedetti FAM: The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin. / Prog Neurobiol 1997, 52:109. CrossRef
    22. Kenia P, Houghton T, Beardsmore C: Does inhaling menthol affect nasal patency or cough? / Pediatr Pulmonol 2008, 43:532鈥?37. CrossRef
    23. Ramsay J, Wright C, Thompson R, et al.: Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures. / Br J Clin Pharmacol 2008, 65:737鈥?41. CrossRef
    24. Sapci T, Yazici S, Evcimik MF, et al.: Investigation of the effects of intranasal botulinum toxin type A and ipratropium bromide nasal spray on nasal hypersecretion in idiopathic rhinitis without eosinophilia. / Rhinology 2008, 46:45鈥?1.
    25. Jones NS: Midfacial segment pain: implications for rhinitis and sinusitis. / Curr Allergy Asthma Rep 2004, 4:187鈥?92. CrossRef
    26. Naranch K, Park Y-J, Repka-Ramirez SM, et al.: A tender sinus does not always mean sinusitis. / Otolaryngol Head Neck Surg 2002, 127:387鈥?97. CrossRef
    27. Shusterman D, Murphy MA: Nasal hyperreactivity in allergic and non-allergic rhinitis: a potential risk factor for non-specific building-related illness. / Indoor Air 2007, 17:328鈥?33. CrossRef
    28. Elsheikh MN, Badran HM: Dysautonomia rhinitis: associated otolaryngologic manifestations and characterization based on autonomic function tests. / Acta Otolaryngol 2006, 126:1206鈥?212. CrossRef
  • 作者单位:James N. Baraniuk (1)

    1. Division of Rheumatology, Immunology and Allergy, Room B105, Lower Level Kober-Cogan Building, Georgetown University, 3800 Reservoir Road, NW, Washington, DC, 20007-2197, USA
文摘
Many common treatments for rhinitis symptoms are inadequate or ineffective. This may be in part because the drug does not address the pathologically altered mechanism of the rhinopathy. Objective measures may not detect treatment effects, or the treatment end points may be only subjective in nature. In many cases, these issues have not arisen because of potent placebo effects. Understanding the psychological, pharmacologic, and physiologic components of placebos is important for separating true treatment effects from those of the excipients in the vehicle. Separating the wasteful and potentially harmful effects of those excipients from the harmless and often partially beneficial effects on temporary symptom control is an important issue in clinical pharmacology that can aid in effective clinical trial design, use of objective and subjective test measures, and development of drugs to treat rhinitis.

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