The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms

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• 作者：Wei Ling Lau ; Branko N. Huisa ; Mark Fisher
• 关键词：Cerebrovascular disease ; Blood ; brain barrier ; Chronic kidney disease ; Microalbuminemia ; Arteriolosclerosis ; Arterial medial calcification ; Hypertension
• 刊名：Translational Stroke Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：8
• 期：1
• 页码：67-76
• 全文大小：875KB
• 刊物主题：Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery;
• 出版者：Springer US
• ISSN：1868-601X
• 卷排序：8

文摘

Chronic kidney disease (CKD) is an independent risk factor for the development of cerebrovascular disease, particularly small vessel disease which can manifest in a variety of phenotypes ranging from lacunes to microbleeds. Small vessel disease likely contributes to cognitive dysfunction in the CKD population. Non-traditional risk factors for vascular injury in uremia include loss of calcification inhibitors, hyperphosphatemia, increased blood pressure variability, elastinolysis, platelet dysfunction, and chronic inflammation. In this review, we discuss the putative pathways by which these mechanisms may promote cerebrovascular disease and thus increase risk of future stroke in CKD patients.