Enhanced brain distribution of carboplatin in a primate model after blood–brain barrier disruption using an implantable ultrasound device

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• 作者：Lauriane Goldwirt ; Michael Canney…
• 关键词：Carboplatin ; Brain distribution ; Blood–brain barrier opening ; Unfocused ultrasound
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：77
• 期：1
• 页码：211-216
• 全文大小：648 KB
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• 作者单位：Lauriane Goldwirt (1)
  Michael Canney (2)
  Catherine Horodyckid (2) (3)
  Joel Poupon (4)
  Samia Mourah (1) (5)
  Alexandre Vignot (2)
  Jean-Yves Chapelon (6)
  Alexandre Carpentier (2) (3) (7)
  
  1. Pharmacology Department, Saint-Louis Hospital, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France
  2. CarThera Research Team, Brain and Spine Institute, Paris, France
  3. Neurosurgery Department, Pitie-Salpetriere Hospital, AP-HP, 75013, Paris, France
  4. Toxicology Department, Lariboisiere Hospital, AP-HP, 75010, Paris, France
  5. Faculté UFR de MÉDECINE Paris 7 Diderot, School of Medicine, Paris VII, Paris, France
  6. Inserm, U1032, LabTau, 69003, Lyon, France
  7. School of Medicine, Paris VI Sorbonne University, Paris, France
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843

文摘

Purpose Glioblastoma is both the most common and aggressive primary brain tumor in adults. Carboplatin chemotherapy has shown only modest efficacy in progressive high-grade gliomas. The limited clinical efficacy of carboplatin may be due to its low concentration in tissue when the drug is delivered intravenously. The aim of this study was to assess whether the tissue concentration of intravenously administered carboplatin could be enhanced by ultrasound-induced blood–brain disruption in a primate model.