Le prélèvement de tissu adipeux: un acte médical pour la recherche clinique. Perspectives pour le soin courant

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• 作者：L. Genser (1) (2)
  C. Vatier (1) (3) (4)
  M. Keophyphath (5)
  J. Aron-Wisnewsky (1) (3) (6)
  C. Poitou (1) (3) (6)
  K. Clément (1) (3) (6)
  J. -P. Bastard (1) (4) (7)
  
• 关键词：Tissu adipeux sous ; cutané ; Aspiration à l’aiguille ; Biopsie chirurgicale ; Obésité ; Phénotypage ; Adipocytes ; Subcutaneous adipose tissue ; Needle aspiration ; Surgical biopsy ; Obesity ; Phenotyping ; Adipocytes
• 刊名：Ob篓娄sit篓娄
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：8
• 期：4
• 页码：222-227
• 全文大小：187 KB
• 作者单位：L. Genser (1) (2)
  C. Vatier (1) (3) (4)
  M. Keophyphath (5)
  J. Aron-Wisnewsky (1) (3) (6)
  C. Poitou (1) (3) (6)
  K. Clément (1) (3) (6)
  J. -P. Bastard (1) (4) (7)
  
  1. Institut de cardiométabolisme et nutrition, ICAN, h?pital Pitié-Salpêtrière, Paris, France
  2. Assistance Publique-H?pitaux de Paris, (AP/HP), h?pital Pitié-Salpêtrière, service de chirurgie digestive, hépato-bilio-pancréatique et transplantation hépatique, F-75013, Paris, France
  3. Assistance Publique-H?pitaux de Paris (AP/HP), h?pital Pitié-Salpêtrière, service de nutrition, F-75013, Paris, France
  4. Inserm, Université Pierre et Marie-Curie-Paris 6, UMRS_938, CDR Saint-Antoine, 75012, Paris, France
  5. AdipoPhyt SAS, 75013, Paris, France
  6. Inserm, Université Pierre et Marie-Curie-Paris 6, UMRS Nutriomique U872 Equipe 7, Centre de recherche des Cordeliers, F-75006, Paris, France
  7. Assistance Publique-H?pitaux de Paris (AP/HP), h?pital Tenon, service de biochimie et hormonologie, F-75020, Paris, France
  
• ISSN：1951-6002

文摘

Adipose tissue (AT) is now well recognized as an endocrine organ involved in energy homeostasis regulation acting both on the central nervous system and at the local level via its hormonal secretion such as leptin. Recently, the abdominal subcutaneous AT, which is easily accessible by using several procedures, became one of the important parameters used to phenotype morbidly obese patients. Indeed, morphologic and functional modifications such as, adipocyte hypertrophia, inflammation and fibrosis are associated with obesity-related metabolic complications. The objectives of this article are to present the various techniques of abdominal subcutaneous AT biopsies, as well as further information which they can bring. The less morbid technique is the subcutaneous AT needle aspiration, which is currently used in several indications including morbidly obese patient phenotyping. However, it does not allow a complete histological study because it generally provides unstructured AT samples. Surgical AT biopsy, which requires a cutaneous section, is more invasive than the needle aspiration. However, it allows a good quality complete histological study, but with a lesser AT amount than the needle aspiration.