Adiponectine et carcinogenèse mammaire : r?le physiopathologique et intérêt thérapeutique
详细信息 查看全文
- 作者：B. Fève (1) (2) (3)
J. -P. Bastard (1) (2) (4) - 关键词：Adiponectine ; Adipokines ; Cancer du sein ; Obésité ; Adiponectin ; Adipokines ; Breast cancer ; Obesity
- 刊名：Ob篓娄sit篓娄
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：9
- 期：3
- 页码：191-196
- 全文大小：113 KB
- 参考文献：1. Hulka BS, Moorman PG (2001) Breast cancer: hormones and other risk factors. Maturitas 38: 103-13. p://dx.doi.org/10.1016/S0378-5122(00)00196-1" target="_blank" title="It opens in new window">CrossRef
2. Key J, Hodgson S, Omar RZ et al (2006) Meta-analysis of studies of alcohol and breast cancer with considerations of the methodological issues. Cancer Causes Control 17:759-70 p://dx.doi.org/10.1007/s10552-006-0011-0" target="_blank" title="It opens in new window">CrossRef
3. Baan R, Staif K, Grosse Y et al (2007) Carcinogenicity of alcoholic beverages. Lancet Oncol 8:292-93. p://dx.doi.org/10.1016/S1470-2045(07)70099-2" target="_blank" title="It opens in new window">CrossRef
4. Vainio H, Kaaks R, Bianchini F (2002) Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 11 (suppl 2):S94-00.
5. Renehan AG, Tyson M, Egger M et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371: 569-78 p://dx.doi.org/10.1016/S0140-6736(08)60269-X" target="_blank" title="It opens in new window">CrossRef
6. Rack B, Andergassen U, Neugebauer J et al (2010) The German SUCCESS C Study-The first European Lifestyle Study on breast cancer. Breast Care (Basel) 5: 395-00 p://dx.doi.org/10.1159/000322677" target="_blank" title="It opens in new window">CrossRef
7. Danaei G, Vander Hoorn S, Lopez AD et al (2005) Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 366: 1784-793 p://dx.doi.org/10.1016/S0140-6736(05)67725-2" target="_blank" title="It opens in new window">CrossRef
8. Carmichael AR (2006) Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 113: 1160-166 p://dx.doi.org/10.1111/j.1471-0528.2006.01021.x" target="_blank" title="It opens in new window">CrossRef
9. Abrahamson PE, Gammon MD, Lund MJ et al (2006) General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiol Biomarkers Prev 15: 1871-877 p://dx.doi.org/10.1158/1055-9965.EPI-06-0356" target="_blank" title="It opens in new window">CrossRef
10. Porter GA, Inglis KM, Wood LA et al (2006) Effect of obesity on presentation of breast cancer. Ann Surg Oncol 13: 327-32 p://dx.doi.org/10.1245/ASO.2006.03.049" target="_blank" title="It opens in new window">CrossRef
11. Calle EE, Thun MJ (2004) Obesity and cancer. Oncogene 23:6365-378. p://dx.doi.org/10.1038/sj.onc.1207751" target="_blank" title="It opens in new window">CrossRef
12. Law JH, Habibi G, Hu K et al (2008) Phosphorylated insulin-like growth factor.insulin receptor is present in all cancer subtypes and is related to poor survival. Cancer Res 68: 10238-0246.
13. Chan BT, Lee AV (2008) Insulin receptor substrates (IRSs) and breast tumorigenesis. J Mammary Gland Neoplasia 13: 415-22. p://dx.doi.org/10.1007/s10911-008-9101-9" target="_blank" title="It opens in new window">CrossRef
14. LeRoith D, Roberts CT (2003) The insulin-like growth factor system and cancer. Cancer Lett 195: 127-37 p://dx.doi.org/10.1016/S0304-3835(03)00159-9" target="_blank" title="It opens in new window">CrossRef
15. Weisberg SP, McCann D, Desai M et al (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-808 p://dx.doi.org/10.1172/JCI200319246" target="_blank" title="It opens in new window">CrossRef
16. Harris HR, Tworoger SS, Hankinson SS et al (2011) Plasma leptin levels and risk of breast cancer in premenopausal women. Cancer Prev Res (Phila) 4: 1449-456 p://dx.doi.org/10.1158/1940-6207.CAPR-11-0125" target="_blank" title="It opens in new window">CrossRef
17. Garofalo C, Koda M, Gascio S et al (2006) Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12: 1447-453 p://dx.doi.org/10.1158/1078-0432.CCR-05-1913" target="_blank" title="It opens in new window">CrossRef
18. Ishikawa M, Kitayama J, Nagawa H (2004) Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10: 4325-331 p://dx.doi.org/10.1158/1078-0432.CCR-03-0749" target="_blank" title="It opens in new window">CrossRef
19. Chagnon YC, Wilmore JH, Borecki IB et al (2000) Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 85: 29-4
20. Mammès O, Betoulle D, Aubert R et al (2000) Association of the G-2548A polymorphism in the 50 region of the LEP gene with overweight. Ann Hum Genet 64: 391-94 p://dx.doi.org/10.1017/S0003480000008277" target="_blank" title="It opens in new window">CrossRef
21. Terrasi M, Fiorio E, Mercanti A (2009) Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells. Int J Cancer 125: 1038-044
22. Villareal-Molina MT, Antuna-Puente B (2012) Adiponectin: antiinflammatory and cardioprotective effects. Biochimie 94:2143-149 p://dx.doi.org/10.1016/j.biochi.2012.06.030" target="_blank" title="It opens in new window">CrossRef
23. Tishinsky JM, Robinson LE, Dyck DJ (2012) Insulin-sensitizing properties of adiponectin. Biochimie 94:2131-136 p://dx.doi.org/10.1016/j.biochi.2012.01.017" target="_blank" title="It opens in new window">CrossRef
24. Ohashi K, Ouchi N, Matzuzawa Y (2012) Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie 94:2137-142 p://dx.doi.org/10.1016/j.biochi.2012.06.008" target="_blank" title="It opens in new window">CrossRef
25. Miyoshi Y, Funahashi T, Kihara S et al (2003) Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 9:5699-704
26. Mantzoros C, Petridou E, Dessiprys N et al (2004) Adiponectin and breast cancer risk. J Clin Endocrinol Metab 89:1102-107 p://dx.doi.org/10.1210/jc.2003-031804" target="_blank" title="It opens in new window">CrossRef
27. Tworoger SS, Eliassen AH, Kelesidis T et al (2007) Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab 92:1510-516 p://dx.doi.org/10.1210/jc.2006-1975" target="_blank" title="It opens in new window">CrossRef
28. Petridou E, Mantzoros C, Dessiprys N et al (2003) Plasma adiponectin concentrations in relation to endometrial cancer: a casecontrol study in Greece. J Clin Endocrinol Metab 88:993-97 p://dx.doi.org/10.1210/jc.2002-021209" target="_blank" title="It opens in new window">CrossRef
29. Dal Maso L, Augustin LS, Karalis A, et al (2004) Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab 89:1160-163 p://dx.doi.org/10.1210/jc.2003-031716" target="_blank" title="It opens in new window">CrossRef
30. Michalakis K, Williams CJ, Mitsiades N et al (2007) Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev 16:308-13 p://dx.doi.org/10.1158/1055-9965.EPI-06-0621" target="_blank" title="It opens in new window">CrossRef
31. Li H, Stampfer MJ, Mucci L et al (2010) A 25-year prospective study on plasma adiponectin and leptin concentrations and prostate cancer risk and survival. Clin Chem 56:34-3 p://dx.doi.org/10.1373/clinchem.2009.133272" target="_blank" title="It opens in new window">CrossRef
32. Wei EK, Giovannucci E, Fuchs CS et al (2005) Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst 97:1688-694 p://dx.doi.org/10.1093/jnci/dji376" target="_blank" title="It opens in new window">CrossRef
33. Ishikawa M, Kitayama J, Kazama S et al (2005) Plasma adiponectin and gastric cancer. Clin Cancer Res 11:466-72 p://dx.doi.org/10.1158/1078-0432.CCR-04-1453" target="_blank" title="It opens in new window">CrossRef
34. Pfeiler G, Hudelist G, Wulfing P et al (2010) Impact of AdipoR1 expression on breast cancer development. Gynecol Oncol 117:134-38 p://dx.doi.org/10.1016/j.ygyno.2009.12.018" target="_blank" title="It opens in new window">CrossRef
35. Gialamas SP, Petridou ET, Tseleni-Balafouta S et al (2011) Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metab Clin Exp 60:1530-58 p://dx.doi.org/10.1016/j.metabol.2011.03.020" target="_blank" title="It opens in new window">CrossRef
36. Byeon JS, Jeong JY, Kim MJ et al (2010) Adiponectin and adiponectin receptor expression in relation to colorectal cancer progression. Int J Cancer 127:2758-767
37. Kaklamani VG, Sadim M, His A et al (2008) Variants of the adiponectin and the adiponectin receptor 1 genes and breast cancer risk. Cancer Res 68:3178-184 p://dx.doi.org/10.1158/0008-5472.CAN-08-0533" target="_blank" title="It opens in new window">CrossRef
38. Cong L, Gasser J, Zhao J et al (2007) Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells. Encocrine Related Cancer 14:713-20 p://dx.doi.org/10.1677/ERC-07-0065" target="_blank" title="It opens in new window">CrossRef
39. Bub JD, Miyazaki T, Iwamoto Y (2006) Adiponectin as a growth inhibitor in prostate cancer cells. Biochem Biophys Res Commun 340:1158-166 p://dx.doi.org/10.1016/j.bbrc.2005.12.103" target="_blank" title="It opens in new window">CrossRef
40. Zakikhani M, Dowling RJ, Sonenberg N et al (2008) The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res 1:369-75 p://dx.doi.org/10.1158/1940-6207.CAPR-08-0081" target="_blank" title="It opens in new window">CrossRef
41. Ishikawa M, Kitayama J, Yamauchi T et al (2007) Adiponectin inhibits growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdpoR1 and AdipoR2. Cancer Sci 98:1120-127 p://dx.doi.org/10.1111/j.1349-7006.2007.00486.x" target="_blank" title="It opens in new window">CrossRef
42. Kang JH, Lee YY, Yu BY et al (2005) Adioponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cells. Arch Pharmacol Res 28:1263-269 p://dx.doi.org/10.1007/BF02978210" target="_blank" title="It opens in new window">CrossRef
43. Wang Y, Lam JB, Lam KS et al (2006) Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mide. Cancer Res 66:11462-1470 p://dx.doi.org/10.1158/0008-5472.CAN-06-1969" target="_blank" title="It opens in new window">CrossRef
44. Dos Santos E, Benaitreau D, Dieudonne MN et al (2008) Adiponectin mediates an antiproliferative response in human MDAMB-231 breast cancer cells. Oncol Reports 20:971-77
45. Dieudonne MN, Bussiere M, Dos Santos E et al (2006) Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun 345:271-79 p://dx.doi.org/10.1016/j.bbrc.2006.04.076" target="_blank" title="It opens in new window">CrossRef
46. Arditi JD, Venihaki M, Karalis KP et al (2007) Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res 39:9-3 p://dx.doi.org/10.1055/s-2007-956518" target="_blank" title="It opens in new window">CrossRef
47. Li G, Cong L, Gasser J et al (2011) Mechanisms underlying the antiproliferative actions of adiponectin in human breast cancer cells, MCF7-dependency on the cAMP/protein kinase-A pathway. Nutr Cancer 63:80-8 p://dx.doi.org/10.1080/01635581.2011.596645" target="_blank" title="It opens in new window">CrossRef
48. Grossmann ME, Nkhata KJ, Mizuno NK et al (2008) Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer 370-9
49. Grossmann ME, Ray A, Dogan S et al (2008) Balance of adiponectin and leptin modulates breast cancer cell growth. Cell Res 18:1154-156 p://dx.doi.org/10.1038/cr.2008.293" target="_blank" title="It opens in new window">CrossRef
50. Kamada Y, Matsumoto H, Tamura S et al (2007) Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitits mouse model. J Hepatol 47:556-64 p://dx.doi.org/10.1016/j.jhep.2007.03.020" target="_blank" title="It opens in new window">CrossRef
51. Fujizawa T, Endo H, Tomimoto A et al (2008) Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57:1531-538 p://dx.doi.org/10.1136/gut.2008.159293" target="_blank" title="It opens in new window">CrossRef
52. Lam JB, Chow KH, Xu A et al (2009) Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by molulation of phosphatase and tensin homolog activities. PlosOne e4968
53. Denzel MS, Hennard RW, Shostak G et al (2009) Adiponectin deficiciency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Clin Cancer Res 15:3256-264 p://dx.doi.org/10.1158/1078-0432.CCR-08-2661" target="_blank" title="It opens in new window">CrossRef
54. Landskroner-Eiger S, Qian B, Muise ES et al (2009) Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res 15:3265-276 p://dx.doi.org/10.1158/1078-0432.CCR-08-2649" target="_blank" title="It opens in new window">CrossRef
55. Otani K, Kitayama J, Yasuda K et al (2010) Adiponectin suppreses tumorigenesis in APC(Min)(/+) mice. Cancer Lett 288:177-82 p://dx.doi.org/10.1016/j.canlet.2009.06.037" target="_blank" title="It opens in new window">CrossRef
56. Wang Y, Lam KS, Xu JY et al (2005) Adiponectin inhibits cell proliferation by interacting with several growth factors in a oligomerization-dependent manner. J Biol Chem 280:18341-8347 p://dx.doi.org/10.1074/jbc.M501149200" target="_blank" title="It opens in new window">CrossRef
57. Man K, Ng KT, Xu A et al (2010) Suppression of liver tumor growth and metastatasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. Clin Cancer Res 16:967-77 p://dx.doi.org/10.1158/1078-0432.CCR-09-1487" target="_blank" title="It opens in new window">CrossRef
58. Otvos L, Haspinger E, La Russa F et al (2011) Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotecnhol 11: 90. doi: 10.1186/1472-6750-11-90. p://dx.doi.org/10.1186/1472-6750-11-90" target="_blank" title="It opens in new window">CrossRef
59. Grossmann ME, Cleary MP (2012) The balance between leptin and adiponectin in the control of carcinogenesis: focus on mammary tumorigenesis. Biochimie 94: 2164-171 p://dx.doi.org/10.1016/j.biochi.2012.06.013" target="_blank" title="It opens in new window">CrossRef - 作者单位：B. Fève (1) (2) (3)
J. -P. Bastard (1) (2) (4)
1. Centre de Recherche Saint-Antoine, Université Pierre et Marie Curie, INSERM (UMR_S938), 75012, Paris, France
2. Institut de cardiométabolisme et nutrition, ICAN, Paris, France
3. Service d’Endocrinologie, h?pital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75012, Paris, France
4. Service de Biochimie et Hormonologie, h?pital Tenon, Paris, France - ISSN：1951-6002
文摘
A large number of studies indicate that a growing part of cancers are influenced by obesity. In obese individuals, cancers are more frequent and more aggressive, especially for post-menopausal breast cancer. The pathophysiological mechanisms that underlie the relationship between obesity and breast cancer carcinogenesis are complex and associate both an increased inflammation and angiogenesis, and altered plasma levels of several growth factors and hormones including insulin, IGF-1, adiponectin, leptin, and oestrogens.More specifically, a sum of epidemiological, genetic, and experimental studies converge to suggest an anti-carcinogenic role for adiponectin. This could lead to the development of new therapeutic strategies through a modulation of the signaling of this adipose tissue-derived hormone.