Appetite control and gastrointestinal hormonal behavior (CCK, GLP-1, PYY 16) following low doses of a whey protein-rich nutraceutic

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• 作者：Samir Giuseppe Sukkar (1)
  Alberto Vaccaro (1)
  Giovanni Battista Ravera (2)
  Claudia Borrini (1)
  Raffaella Gradaschi (1)
  Anna Massa Sacchi-Nemours (1)
  Renzo Cordera (3)
  Gabriella Andraghetti (3)
  
• 关键词：Whey protein ; Appetite suppressant ; GI hormones ; CCK ; GLP ; 1 ; PYY ; Obesity
• 刊名：Mediterranean Journal of Nutrition and Metabolism
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：6
• 期：3
• 页码：259-266
• 全文大小：
• 作者单位：Samir Giuseppe Sukkar (1)
  Alberto Vaccaro (1)
  Giovanni Battista Ravera (2)
  Claudia Borrini (1)
  Raffaella Gradaschi (1)
  Anna Massa Sacchi-Nemours (1)
  Renzo Cordera (3)
  Gabriella Andraghetti (3)
  
  1. Clinical Nutrition Unit, IRCCS Azienda Ospedaliera Universitaria San Martino-IST di Genova, Genova, Italy
  2. Bio Statistical Institute, Health Science Department (DISSAL), Genoa University, Largo R. Benzi 2, 16122, Genova, Italy
  3. Department of Endocrinology and Metabolism, IRCCS Azienda Ospedaliera Universitaria San Martino-IST di Genova, Genova, Italy
  
• ISSN：1973-7998

文摘

Whey proteins represent the most satiating nutrients. In particular, their effects are due to enterohormonal changes (CCK, GLP-1 and PYY 16) observed after their exclusive ingestion. Glucomannan has important satiety property due to volume increase following gelification. The aim of the study is the evaluation of subjective rate of hunger and enterohormone concentrations (CCK, GLP-1, PYY 16) following oral loading of a mixture containing WP (8g) or casein (8g) plus glucomannan (1g) (Colordiet, Inpha DUEMILA Srl Lecco, Italy). The study was conducted as a double-blind crossover with five healthy volunteers (BMI 226kg/m2 aging 185years) in acute and a wash-out period of 1week between the first and the second evaluation. From the analysis of the data, we observe that the load with WP induces a significant decrease in the desire to eat after 90min (P<0.0446) when compared with casein. As far as plasma hormones are concerned, there was a significant increase only in GLP-1 at 90min after WP (P<0.00166) and 180min after casein (T0 vs. T180 P=0.000129). There is a significant correlation between the increase in GLP-1 and decrease of desire to eat (R=0.93). There is a tendency to the increasing of CCK after 90min, which is not significant (P=0.091). These results could be due to (a) the low number of cases or (b) the low dose of protein used. The present study suggests that a mixture of WP plus glucomannan exerts a decrease in the desire to eat which is correlated to enterohormonal modification (GLP-1 increase) despite the low content of protein (8g) and the presence of glucomannan, which could reduce the fast absorption of WP in relation to the net forming during the gelification of the gastric environment.