The anxiolytic effects of a Valerian extract is based on Valerenic acid

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• 作者：Axel Becker ; Falko Felgentreff…
• 关键词：Valerian extract ; Valerenic acid ; Elevated plus maze ; Anxiety ; Binding
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：385 KB
• 参考文献：1. Benke, D, Barberis, A, Kopp, S, Altmann, KH, Schubiger, M, Vogt, KE, Rudolph, U, M?hler, H (2009) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56: pp. 174-181 CrossRef
  2. Khom, S, Strommeier, B, Ramharter, J, Schwarz, T, Schwarzer, C, Erker, T, Ecker, GF, Mulzer, J, Hering, S (2010) Valerenic acid derivatives as novel subunit-selective ligands -in vitro and in vivo characterization. Br J Pharmacol 161: pp. 65-78 CrossRef
  3. Murphy, K, Kubin, ZJ, Shepherd, JN, Ettinger, RH (2010) Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine 17: pp. 674-678 CrossRef
  4. Khom, S, Baburin, I, Timin, E, Hohaus, A, Trauner, G, Kopp, B, Hering, S (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacology 53: pp. 178-187 CrossRef
  5. Trauner, G, Khom, S, Baburin, I, Benedek, B, Hering, S, Kopp, B (2007) Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med 74: pp. 19-24 CrossRef
  6. Felgentreff, F, Becker, A, Meier, B, Brattstr?m, A (2012) Valerian extract characterized by high valerenic acid and low azetoxy valerenic acid contents demonstrates anxiolytic activity. Phytomedicine 19: pp. 1216-1222 CrossRef
  7. Navarrete, A, Avula, B, Choi, YW (2006) Chemical fingerprinting of valerian species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. J AOAC Int 89: pp. 8-18
  8. Yakimova, KS, Sann, H, Schmid, HA, Pierau, FK (1996) Effects of GABA agonists and antagonists on temperature-sensitive neurons in the rat hypothalamus. J Physiol 494: pp. 217-230
  9. Zarrindast, MR, Dibayan, M (1998) Involvement of GABAA receptor sites in diazepam induced hypothermia. Gen Pharmacol 20: pp. 855-859 CrossRef
  10. Nikolov, RP, Yakimova, KS (2011) Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats. Amino Acids 40: pp. 1441-1445 CrossRef
  11. Rodgers, RJ (1997) Animal models of anxiety: where next?. Behav Pharmacol 8: pp. 477-496 CrossRef
  12. Goppel, M, Franz, G (2003) Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. Pharmazie 59: pp. 446-452
  13. Fernández, S, Wasowski, C, Paladini, AC, Marder, M (2004) Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol Biochem Behav 77: pp. 399-404 CrossRef
  14. Marder, M, Viola, H, Wasowski, C, Fernández, S, Medina, JH, Paladini, AC (2003) 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 75: pp. 537-545 CrossRef
  15. Yuan, CS, Mehendale, S, Xiao, Y, Aung, HH, Xie, JT, Ang-Lee, MK (2004) The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anaesth Analg 98: pp. 353-358 CrossRef
  16. Sampath, C, Haug, K, Thanel, S, Hamburger, M, Derendorf, H, Frye, R, Butterweck, V (2012) Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. Planta Med 78: pp. 575-581 CrossRef
  17. Awad, R, Le
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic acid. In the present experiments it was investigated whether acetoxy valerenic acid may interfere with the anxiolytic action of valerenic acid. Methods Situational anxiety was measured using male CD-1 mice in the elevated plus maze test after oral administration of the test substances. In addition the body core temperature was measured. For the 3H-GABA binding assay dissected tissue from frontal cortex of male RjHan:WI rats were used. Statistical evaluation was performed by means of the non-parametric Kruskal-Wallies H-test, followed by the two-tailed Mann–Whitney U-test. Results Adding of acetoxy valerenic acid abolished the anxiolytic action of valerenic acid. There was no effect on body core temperature. Moreover, the valerian extract did not show any affinity to benzodiazepine binding sites. Conclusion The determining compound for the observed anxiolytic effect of the valerian extract is its content of valerenic acid.