Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion
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- 作者：Scott T. Barrett ; Trevor N. Geary ; Amy N. Steiner ; Rick A. Bevins
- 关键词：Nicotine ; Bupropion ; Sex differences ; Reward enhancement ; Behavioral economics ; Reinforcer demand ; Dopamine ; Rats
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：234
- 期：2
- 页码：187-198
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
RationaleNicotine and bupropion have been demonstrated to enhance the value of other reinforcers, and this may partially account for nicotine reward and dependence. Evidence suggests that the sexes differ in their sensitivity to the primary and secondary reinforcing effects of nicotine and nicotine-associated stimuli. Whether the sexes also differ in sensitivity to the reward-enhancing effects of nicotine (and bupropion) is yet unclear.