Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders
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- 作者：Margarita C. T. Slof-Op’t Landt (1) (2) (3)
Meike Bartels (3)
Christel M. Middeldorp (3) (4) (5)
Catherina E. M. van Beijsterveldt (3)
P. Eline Slagboom (2) (6)
Dorret I. Boomsma (3)
Eric F. van Furth (1)
Ingrid Meulenbelt (2) - 关键词：Eating disorders ; Perfectionism ; Impulsivity ; TPH2 ; Association analysis
- 刊名：Behavior Genetics
- 出版年：2013
- 出版时间：January 2013
- 年：2013
- 卷：43
- 期：1
- 页码：24-33
- 全文大小：236KB
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Meike Bartels (3)
Christel M. Middeldorp (3) (4) (5)
Catherina E. M. van Beijsterveldt (3)
P. Eline Slagboom (2) (6)
Dorret I. Boomsma (3)
Eric F. van Furth (1)
Ingrid Meulenbelt (2)
1. Center for Eating Disorders Ursula, P. O. Box 422, 2260 AK, Leidschendam, The Netherlands
2. Department of Medical Statistics, Molecular Epidemiology Section, Leiden University Medical Centre, Leiden, The Netherlands
3. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
4. Department of Child and Adolescent Psychiatry, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
5. Department of Child and Adolescent Psychiatry, GGZ inGeest, VU Medical Center, Amsterdam, The Netherlands
6. Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands - ISSN：1573-3297
文摘
Genes are involved in eating disorders (EDs) and self-induced vomiting (SV), a key symptom of different types of EDs. Perfectionism and impulsivity are potential risk factors for EDs. TPH2 (tryptophan hydroxylase 2) SNP rs1473473 was previously associated with anorexia nervosa and EDs characterized by SV. Could perfectionism or impulsivity be underlying the association between rs1473473 and EDs? Genetic association between TPH2 SNP rs1473473 and perfectionism or impulsivity was first evaluated in a random control group (N?=?512). The associations obtained in this control group were subsequently tested in a group of patients with an ED (N?=?267). The minor allele of rs1473473 (OR?=?1.49) was more frequent in impulsive controls, but also in impulsive patients with an ED (OR?=?1.83). The largest effect was found in the patients with an ED characterized by SV (OR?=?2.51, p?=?0.02). Genetic variation at the TPH2 gene appeared to affect impulsivity which, in turn, might predispose to the SV phenotype.