The relation of C - reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study

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• 作者：Ervin R Fox (1)
  Emelia J Benjamin (2)
  Daniel F Sarpong (3)
  Harsha Nagarajarao (1)
  Jason K Taylor (1)
  Michael W Steffes (4)
  Abdullah K Salahudeen (5)
  Michael F Flessner (1)
  Ermeg L Akylbekova (1) (3)
  Caroline S Fox (6)
  Robert J Garrison (1)
  Herman A Taylor Jr (1) (3)
  
• 刊名：BMC Nephrology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：11
• 期：1
• 全文大小：247KB
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  37. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2369/11/1/prepub
  
• 作者单位：Ervin R Fox (1)
  Emelia J Benjamin (2)
  Daniel F Sarpong (3)
  Harsha Nagarajarao (1)
  Jason K Taylor (1)
  Michael W Steffes (4)
  Abdullah K Salahudeen (5)
  Michael F Flessner (1)
  Ermeg L Akylbekova (1) (3)
  Caroline S Fox (6)
  Robert J Garrison (1)
  Herman A Taylor Jr (1) (3)
  
  1. Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA
  2. Department of Medicine, Boston University School of Medicine, School of Public Health, Boston, MA, USA
  3. Jackson Heart Study, Jackson State University, Jackson, MS, USA
  4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
  5. Section of Nephrology, Department of General Internal Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  6. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
  

文摘

Background African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD - estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on the role of inflammation in renal dysfunction in African Americans in the community. Methods We examined the cross-sectional relation of log transformed C-reactive protein (CRP) to renal function (eGFR by Modification of Diet and Renal Disease equation) in African American participants of the community-based Jackson Heart Study's first examination (2000 to 2004). We conducted multivariable linear regression relating CRP to eGFR adjusting for age, sex, body mass index, systolic and diastolic blood pressure, diabetes, total/HDL cholesterol, triglycerides, smoking, antihypertensive therapy, lipid lowering therapy, hormone replacement therapy, and prevalent cardiovascular disease events. In a secondary analysis we assessed the association of CRP with albuminuria (defined as albumin-to-creatinine ratio > 30 mg/g). Results Participants (n = 4320, 63.2% women) had a mean age ± SD of 54.0 ± 12.8 years. The prevalence of CKD was 5.2% (n = 228 cases). In multivariable regression, CRP concentrations were higher in those with CKD compared to those without CKD (mean CRP 3.2 ± 1.1 mg/L vs. 2.4 ± 1.0 mg/L, respectively p < 0.0001). CRP was significantly associated with albuminuria in sex and age adjusted model however not in the multivariable adjusted model (p > 0.05). Conclusion CRP was associated with CKD however not albuminuria in multivariable-adjusted analyses. The study of inflammation in the progression of renal disease in African Americans merits further investigation.