A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion

详细信息    查看全文

• 作者：Benjamin D. Elder ; Christina Holmes ; C. Rory Goodwin…
• 关键词：Growth factors ; Bone regeneration ; Scaffold ; Tissue engineering ; TGF ; 尾
• 刊名：Annals of Biomedical Engineering
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：43
• 期：5
• 页码：1057-1070
• 全文大小：601 KB
• 参考文献：1.Acebal-Cortina, G., M. A. Suarez-Suarez, C. Garcia-Menendez, L. Moro-Barrero, R. Iglesias-Colao, and A. Torres-Perez. Evaluation of autologous platelet concentrate for intertransverse lumbar fusion. Eur. Spine J. 20(Suppl 3):361鈥?66, 2011.View Article PubMed Central PubMed
  2.Alsousou, J., M. Thompson, P. Hulley, A. Noble, and K. Willett. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J. Bone Joint Surg. Br. 91:987鈥?96, 2009.View Article PubMed
  3.Auerbach, J. D., K. B. McGowan, M. Halevi, M. C. Gerling, A. D. Sharan, P. G. Whang, et al. Mitigating adverse event reporting bias in spine surgery. J. Bone Joint Surg. Am. 95:1450鈥?456, 2013.View Article PubMed
  4.Boden, S. D., J. Kang, H. Sandhu, and J. G. Heller. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976) 27:2662鈥?673, 2002.View Article
  5.Bose, B., and M. A. Balzarini. Bone graft gel: autologous growth factors used with autograft bone for lumbar spine fusions. Adv. Ther. 19:170鈥?75, 2002.View Article PubMed
  6.Bydon Macki, M., N. B. Abt, T. F. Witham, J. P. Wolinsky, Z. L. Gokaslan, et al. The cost-effectiveness of interbody fusions versus posterolateral fusions in 137 patients with lumbar spondylolisthesis. Spine J. 15:492鈥?98, 2015.View Article
  7.Carragee, E. J., E. L. Hurwitz, and B. K. Weiner. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 11:471鈥?91, 2011.View Article PubMed
  8.Carreon, L. Y., S. D. Glassman, Y. Anekstein, and R. M. Puno. Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions. Spine (Phila Pa 1976) 30:E243鈥?46, 2005; (discussion E247).View Article
  9.Castro, Jr., F. P. Role of activated growth factors in lumbar spinal fusions. J. Spinal Disord. Tech. 17:380鈥?84, 2004.View Article PubMed
  10.Cinotti, G., A. Corsi, B. Sacchetti, M. Riminucci, P. Bianco, and G. Giannicola. Bone ingrowth and vascular supply in experimental spinal fusion with platelet-rich plasma. Spine (Phila Pa 1976) 38:385鈥?91, 2013.View Article
  11.Cmolik, B. L., J. A. Spero, G. J. Magovern, and R. E. Clark. Redo cardiac surgery: late bleeding complications from topical thrombin-induced factor V deficiency. J. Thorac. Cardiovasc. Surg. 105:222鈥?27, 1993; (discussion 227鈥?28).PubMed
  12.Coseo, N. M., N. Saldua, and J. Harrop. Current use of biologic graft extenders for spinal fusion. J. Neurosurg. Sci. 56:203鈥?07, 2012.PubMed
  13.Cunningham, B. W., J. C. Sefter, N. Hu, and P. C. McAfee. Autologous growth factors versus autogenous graft for anterior cervical interbody fusion: an in vivo caprine model. J. Neurosurg. Spine 13:216鈥?23, 2010.View Article PubMed
  14.Eppley, B. L., J. E. Woodell, and J. Higgins. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast. Reconstr. Surg. 114:1502鈥?508, 2004.View Article PubMed
  15.Feiz-Erfan, I., M. Harrigan, V. K. Sonntag, and T. R. Harrington. Effect of autologous platelet gel on early and late graft fusion in anterior cervical spine surgery. J. Neurosurg. Spine 7:496鈥?02, 2007.View Article PubMed
  16.Gullung, G. B., J. W. Woodall, M. A. Tucci, J. James, D. A. Black, and R. A. McGuire. Platelet-rich plasma effects on degenerative disc disease: analysis of histology and imaging in an animal model. Evid. Based Spine Care J. 2:13鈥?8, 2011.View Article PubMed Central PubMed
  17.Han, B., J. Woodell-May, M. Ponticiello, Z. Yang, and M. Nimni. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J. Bone Joint Surg. Am. 91:1459鈥?470, 2009.View Article PubMed
  18.Hartmann, E. K., T. Heintel, R. H. Morrison, and A. Weckbach. Influence of platelet-rich plasma on the anterior fusion in spinal injuries: a qualitative and quantitative analysis using computer tomography. Arch. Orthop. Trauma Surg. 130:909鈥?14, 2010.View Article PubMed
  19.Hee, H. T., M. E. Majd, R. T. Holt, and L. Myers. Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur. Spine J. 12:400鈥?07, 2003.View Article PubMed Central PubMed
  20.Helm, G. A., H. Dayoub, and J. A. Jane, Jr. Bone graft substitutes for the promotion of spinal arthrodesis. Neurosurg. Focus 10:E4, 2001.PubMed
  21.Hsu, W. K., R. E. Hashimoto, S. H. Berven, and A. Nassr. Biological substitutes/extenders for spinal arthrodesis: which agents are cost-effective? Spine (Phila Pa 1976) 39:S86鈥?8, 2014.View Article
  22.Hsu, W. K., A. Mishra, S. R. Rodeo, F. Fu, M. A. Terry, P. Randelli, et al. Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. J. Am. Acad. Orthop. Surg. 21:739鈥?48, 2013.View Article PubMed
  23.Intini, G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials 30:4956鈥?966, 2009.View Article PubMed
  24.Jenis, L. G., R. J. Banco, and B. Kwon. A prospective study of Autologous Growth Factors (AGF) in lumbar interbody fusion. Spine J. 6:14鈥?0, 2006.View Article PubMed
  25.Kaiser, M. G., M. W. Groff, W. C. Watters, 3rd, Z. Ghogawala, P. V. Mummaneni, A. T. Dailey, et al. Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: bone graft extenders and substitutes as an adjunct for lumbar fusion. J. Neurosurg. Spine 21:106鈥?32, 2014.View Article PubMed
  26.Kamoda, H., S. Ohtori, T. Ishikawa, M. Miyagi, G. Arai, M. Suzuki, et al. The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model. J. Bone Joint Surg. Am. 95:1109鈥?116, 2013.View Article PubMed
  27.Kasten, P., J. Vogel, I. Beyen, S. Weiss, P. Niemeyer, A. Leo, et al. Effect of platelet-rich plasma on the in vitro proliferation and osteogenic differentiation of human mesenchymal stem cells on distinct calcium phosphate scaffolds: the specific surface area makes a difference. J. Biomater. Appl. 23:169鈥?88, 2008.View Article PubMed
  28.Kasten, P., J. Vogel, R. Luginbuhl, P. Niemeyer, S. Weiss, S. Schneider, et al. Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics. Cells Tissues Organs 183:68鈥?9, 2006.View Article PubMed
  29.Kelly, A. M., J. N. Batke, N. Dea, D. P. Hartig, C. G. Fisher, and J. T. Street. Prospective analysis of adverse events in surgical treatment of degenerative spondylolisthesis. Spine J. 14:2905鈥?910, 2014.View Article PubMed
  30.Kim, E. S., J. J. Kim, and E. J. Park. Angiogenic factor-enriched platelet-rich plasma enhances in vivo bone formation around alloplastic graft material. J. Adv. Prosthodont. 2:7鈥?3, 2010.View Article PubMed Central PubMed
  31.Klaassen, M. A., and W. S. Pietrzak. Platelet-rich plasma application and heterotopic bone formation following total hip arthroplasty. J. Invest. Surg. 24:257鈥?61, 2011.View Article PubMed
  32.Kurz, L. T., S. R. Garfin, and R. E. Booth, Jr. Harvesting autogenous iliac bone grafts. A review of complications and techniques. Spine (Phila Pa 1976) 14:1324鈥?331, 1989.View Article
  33.Lacoste, E., I. Martineau, and G. Gagnon. Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release. J. Periodontol. 74:1498鈥?507, 2003.View Article PubMed
  34.Landi, A., R. Tarantino, N. Marotta, A. G. Ruggeri, M. Domenicucci, L. Giudice, et al. The use of platelet gel in postero-lateral fusion: preliminary results in a series of 14 cases. Eur. Spine J. 20(Suppl 1):S61鈥揝67, 2011.View Article PubMed
  35.Li, H., X. Zou, Q. Xue, N. Egund, M. Lind, and C. Bunger. Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs. Eur. Spine J. 13:354鈥?58, 2004.View Article PubMed Central PubMed
  36.Liao, H. T., K. G. Marra, and J. P. Rubin. Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review. Tissue Eng. Part B Rev. 20:267鈥?76, 2014.View Article PubMed
  37.Lowery, G. L., S. Kulkarni, and A. E. Pennisi. Use of autologous growth factors in lumbar spinal fusion. Bone 25:47S鈥?0S, 1999.View Article PubMed
  38.Marlovits, S., M. Mousavi, C. Gabler, J. Erdos, and V. Vecsei. A new simplified technique for producing platelet-rich plasma: a short technical note. Eur. Spine J. 13(Suppl 1):S102鈥揝106, 2004.View Article PubMed Central PubMed
  39.Martin, Jr., G. J., S. D. Boden, M. A. Marone, M. A. Marone, and P. A. Moskovitz. Posterolateral intertransverse process spinal arthrodesis with rhBMP-2 in a nonhuman primate: important lessons learned regarding dose, carrier, and safety. J. Spinal Disord. 12:179鈥?86, 1999.PubMed
  40.Marx, R. E. Platelet-rich plasma: evidence to support its use. J. Oral Maxillofac. Surg. 62:489鈥?96, 2004.View Article PubMed
  41.Marx, R. E., E. R. Carlson, R. M. Eichstaedt, S. R. Schimmele, J. E. Strauss, and K. R. Georgeff. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 85:638鈥?46, 1998.View Article PubMed
  42.Miyazaki, M., H. Tsumura, J. C. Wang, and A. Alanay. An update on bone substitutes for spinal fusion. Eur. Spine J. 18:783鈥?99, 2009.View Article PubMed Central PubMed
  43.Morone, M. A., S. D. Boden, G. Hair, G. J. Martin, Jr., M. Racine, L. Titus, et al. The Marshall R. Urist Young Investigator Award. Gene expression during autograft lumbar spine fusion and the effect of bone morphogenetic protein 2. Clin. Orthop. Relat. Res. 351:252鈥?65, 1998.View Article PubMed
  44.Obata, S., K. Akeda, T. Imanishi, K. Masuda, W. Bae, R. Morimoto, et al. Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study. Arthritis Res. Ther. 14:R241, 2012.View Article PubMed Central PubMed
  45.Okamoto, S., T. Ikeda, K. Sawamura, M. Nagae, H. Hase, Y. Mikami, et al. Positive effect on bone fusion by the combination of platelet-rich plasma and a gelatin beta-tricalcium phosphate sponge: a study using a posterolateral fusion model of lumbar vertebrae in rats. Tissue Eng. Part A 18:157鈥?66, 2012.View Article PubMed
  46.Rajaee, S. S., H. W. Bae, L. E. Kanim, and R. B. Delamarter. Spinal fusion in the United States: analysis of trends from 1998 to 2008. Spine (Phila Pa 1976) 37:67鈥?6, 2012.View Article
  47.Rao, R. D., K. Gourab, V. B. Bagaria, V. B. Shidham, U. Metkar, and B. C. Cooley. The effect of platelet-rich plasma and bone marrow on murine posterolateral lumbar spine arthrodesis with bone morphogenetic protein. J. Bone Joint Surg. Am. 91:1199鈥?206, 2009.View Article PubMed
  48.Rodeo, S. A., S. D. Boden, M. M. Murray, and T. A. Einhorn. 2011 AOA Symposium: tissue engineering and tissue regeneration: AOA critical issues. J. Bone Joint Surg. Am. 95:e109, 2013.View Article PubMed Central PubMed
  49.Rodriguez, I. A., E. A. Growney Kalaf, G. L. Bowlin, and S. A. Sell. Platelet-rich plasma in bone regeneration: engineering the delivery for improved clinical efficacy. Biomed. Res. Int. 2014:392398, 2014.PubMed Central PubMed
  50.Scholz, M., P. Schleicher, T. Eindorf, F. Friedersdorff, M. Gelinsky, U. Konig, et al. Cages augmented with mineralized collagen and platelet-rich plasma as an osteoconductive/inductive combination for interbody fusion. Spine (Phila Pa 1976) 35:740鈥?46, 2010.
  51.Sethi, P. M., J. J. Miranda, S. Kadiyala, T. Patel, M. Panjabi, N. Troiano, et al. Evaluation of autologous platelet concentrate for intertransverse process lumbar fusion. Am. J. Orthop. (Belle Mead NJ) 37:E84鈥揈90, 2008.
  52.Simman, R., A. Hoffmann, R. J. Bohinc, W. C. Peterson, and A. J. Russ. Role of platelet-rich plasma in acceleration of bone fracture healing. Ann. Plast. Surg. 61:337鈥?44, 2008.View Article PubMed
  53.Slater, M., J. Patava, K. Kingham, and R. S. Mason. Involvement of platelets in stimulating osteogenic activity. J. Orthop. Res. 13:655鈥?63, 1995.View Article PubMed
  54.Sys, J., J. Weyler, T. Van Der Zijden, P. Parizel, and J. Michielsen. Platelet-rich plasma in mono-segmental posterior lumbar interbody fusion. Eur. Spine J. 20:1650鈥?657, 2011.View Article PubMed Central PubMed
  55.Tarantino, R., P. Donnarumma, C. Mancarella, M. Rullo, G. Ferrazza, G. Barrella, et al. Posterolateral arthrodesis in lumbar spine surgery using autologous platelet-rich plasma and cancellous bone substitute: an osteoinductive and osteoconductive effect. Glob. Spine J. 4:137鈥?42, 2014.View Article
  56.Tsai, C. H., H. C. Hsu, Y. J. Chen, M. J. Lin, and H. T. Chen. Using the growth factors-enriched platelet glue in spinal fusion and its efficiency. J. Spinal Disord. Tech. 22:246鈥?50, 2009.View Article PubMed
  57.Vadala, G., A. Di Martino, M. C. Tirindelli, L. Denaro, and V. Denaro. Use of autologous bone marrow cells concentrate enriched with platelet-rich fibrin on corticocancellous bone allograft for posterolateral multilevel cervical fusion. J. Tissue Eng. Regen. Med. 2:515鈥?20, 2008.View Article PubMed
  58.Walsh, W. R., A. Loefler, S. Nicklin, D. Arm, R. E. Stanford, Y. Yu, et al. Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic. Eur. Spine J. 13:359鈥?66, 2004.View Article PubMed Central PubMed
  59.Wang, D., H. Jiang, S. Wang, H. Li, H. Zhang, L. Zhao, et al. Construction of tissue-engineered bone using a bioreactor and platelet-rich plasma. Exp. Ther. Med. 8:413鈥?18, 2014.View Article PubMed Central PubMed
  60.Wang, S. Z., Y. F. Rui, Q. Tan, and C. Wang. Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy. Arthritis Res. Ther. 15:220, 2013.View Article PubMed Central PubMed
  61.Wang, C., D. Zhong, X. Zhou, K. Yin, Q. Liao, L. Kong, et al. Preparation of a new composite combining strengthened beta-tricalcium phosphate with platelet-rich plasma as a potential scaffold for the repair of bone defects. Exp. Ther. Med. 8:1081鈥?086, 2014.PubMed Central PubMed
  62.Weibrich, G., T. Hansen, W. Kleis, R. Buch, and W. E. Hitzler. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 34:665鈥?71, 2004.View Article PubMed
  63.Weibrich, G., W. K. Kleis, G. Hafner, and W. E. Hitzler. Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J. Craniomaxillofac. Surg. 30:97鈥?02, 2002.View Article PubMed
  64.Weibrich, G., W. K. Kleis, M. Kunz-Kostomanolakis, A. H. Loos, and W. Wagner. Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor. Int. J. Oral Maxillofac. Implants 16:693鈥?99, 2001.PubMed
  65.Weiner, B. K., and M. Walker. Efficacy of autologous growth factors in lumbar intertransverse fusions. Spine (Phila Pa 1976) 28:1968鈥?970, 2003; (discussion 1971).View Article
  66.Wu, R. H., J. F. Fraser, and R. Hartl. Minimal access versus open transforaminal lumbar interbody fusion: meta-analysis of fusion rates. Spine (Phila Pa 1976) 35:2273鈥?281, 2010.View Article
  
• 作者单位：Benjamin D. Elder (1)
  Christina Holmes (1)
  C. Rory Goodwin (1)
  Sheng-Fu Lo (1)
  Varun Puvanesarajah (1)
  Thomas A. Kosztowski (1)
  John E. Locke (1)
  Timothy F. Witham (1)
  
  1. Department of Neurosurgery, The Johns Hopkins Hospital, 1800 Orleans St., Room 6007, Baltimore, MD, 21287, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

Spinal fusion is one of the most commonly performed procedures for the treatment of spinal instability caused by a multitude of pathologies. However, despite significant advances in spinal instrumentation, failed fusion, or pseudoarthrosis, remains a significant challenge. Therefore, other additives such as bone graft extenders and growth factors have been explored as a method to augment fusion rates. Platelet-rich plasma (PRP) represents an additional approach, as it has shown some promise in bone regeneration. While the general use of PRP in orthopedic applications has been reviewed previously, its use in spinal fusion has not been systematically analyzed. The objective of this review is to systematically discuss the role of PRP in augmentation of bone regeneration for the purpose of spinal fusion. Background information on PRP, including a discussion of its preparation, activation, and growth factors, is included. Additionally, data from in vitro studies utilizing PRP in bone tissue engineering strategies is analyzed, and the available animal and clinical studies are systematically reviewed in order to provide guidance on future research pathways as well as the potential role of PRP in spinal fusion surgery.