刊名:Current Translational Geriatrics and Experimental Gerontology Reports
出版年:2015
出版时间:September 2015
年:2015
卷:4
期:3
页码:257-264
全文大小:825 KB
参考文献:Papers of particular interest, published recently, have been highlighted as: -Of importance1. http://?www.?senescence.?info/?aging_?theories.?html 2.Kirkwood TB. Understanding the odd science of aging. Cell. 2005;120(4):437-7.PubMed View Article 3.Hjelmborg VJ, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, et al. Genetic influence on human lifespan and longevity. Hum Genet. 2006;119(3):312-1.View Article 4.Vaziri H, Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol. 1996;31:295-01.PubMed View Article 5.Davis T et al. Prevention of accelerated cell aging in the Werner syndrome. Ann N Y Acad Sci. 2006;1067:243-.PubMed View Article 6.Manju K, Muralikrishna B, Parnaik VK. Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. J Cell Sci. 2006;119:2704-4.PubMed View Article 7.De la Fuente M, Hernanz A, Vallejo MC. The immune system in the oxidative stress conditions of aging and hypertension: Favorable effects of antioxidants and physical exercise. Antioxid Redox Signal. 2005;7:1356-6.PubMed View Article 8.Sela BA. Dermatological manifestations of smoking. Harefuah. 2002;141(8):736-0.PubMed 9.Wulf HC et al. Skin aging and natural photoprotection. Micron. 2004;35:185-1.PubMed View Article 10.Roskos KV et al. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: The effect of aging on microcirculation. Br J Dermatol. 1990;122:165-1.PubMed View Article 11.Tezuka T et al. Terminal differentiation of facial epidermis of the aged: Immunohistochemical studies. Dermatology. 1994;188:21-.PubMed View Article 12.Plowden J et al. Innate immunity in aging: Impact on macrophage function. Aging Cell. 2004;3:161-.PubMed View Article 13.MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536-.PubMed Central PubMed View Article 14.Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353-3.PubMed View Article 15.Tsuchida Y. The effect of aging and arteriosclerosis on human skin blood flow. J Dermatol Sci. 1993;5:175-1.PubMed View Article 16.Ryan T. The ageing of the blood supply and the lymphatic drainage of the skin. Micron. 2004;35:161-1.PubMed View Article 17.Gerstein AD et al. Wound healing and aging. Dermatol Clin. 1993;11:749-7.PubMed 18.Longo C, Casari A, Beretti F, Cesinaro A, Pellacani.G. Skin aging: In vivo microscopic assessment of epidermal and dermal shcanges by means of confocal microscopy. Jaad Online October, 2011. 19.Armstrong BK, Kricker A. Epidemiology of sun exposure and skin cancer. Cancer Surv. 1996;26:133-3.PubMed 20.Matterne U, Apgelbacher CJ, Vogelgsang L, Loerbroks A, Weisshar E. Incindence and determinants of chronic pruritis: a population-based cohort study. Acta Derm Venereol. 2013;93:532-.PubMed View Article 21.Stander S et al. Clinical classification of itch: A position paper of the International Forum for the study of Itch. Acta Derm Venereol. 2007;87(4):291-.PubMed View Article 22.Shelley WB, Arthur RP. The neurohistology and neurophysiology of the itch sensation in man. AMA Arch Derm. 1957;76(3):296-23.PubMed View Article 23.Schmelz M et al. Specific C-receptors for itch in human skin. J Neurosci. 1997;17(20):8003-.PubMed 24.Berger T, Steinhoff M. Pruritus in elderly patients-eruptions of senescence. Semin Cutaneous Med Surg. 2011;30:113-.View Article 25.Fleicher A. Pruritus in the elderly: managment by senior dermatologists. JAAD. 1993;28:603-.View Article 26.Pisoni RL et al. Pruritus in haemodialysis patients: international results from the dialysis outcomes and practice patterns study (DOPPS). Nephrol Dial Transplant. 2006;21(12):3495-05.PubMed View Article 27.Teoh YL.et al Pruritus in the elderly and its impact on quality of life. Jaad April 2012 Poster Reference number 5327. 28.-/div>Fett N et al. Five-year malignancy incidence in patients with chronic pruritus: a population-based cohort study aimed at limiting unnecessary screening practices. JAAD. 2014;70(4):651-. Patients with chronic pruritus are often extensively worked up for malignancy which drives up health care costs. This paper concludes patient with chronic pruritus without skin findings and no other signs or symptoms of malignancy should not undergo broad screening.View Article 29.Yosipovitch G. Chronic pruritus: a paraneoplastic sign. Dermatol Ther. 2010;23(6):590-.PubMed Central PubMed View Article 30.Sigurdsson V, Steegmans PH, van Vloten WA. The incidence of erythroderma: a survey among all dermatologists in the Netherlands. J Am Acad Dermatol. 2001;45(5):675-.PubMed View Article 31.Rym BM et al. Erythroderma in adults: a report of 80 cases. Int J Dermatol. 2005;44(9):731-.PubMed View Article
作者单位:Brandon Markus (1) Benjamin M. Perry (1) William Lear (1)
The skin is the largest and most visible organ in the body and can give diagnostic clues of systemic illness. These clues often become obscured through the normal aging process. The purpose of this review is to give an overview of the normal skin changes seen with aging and then discuss new findings with regards to cutaneous signs of systemic disease in the elderly. We performed a literature search on cutaneous manifestations of internal disease and limited our search to articles published within the last 5?years. We then narrowed down the articles on conditions that primarily affect the adults over the age of 65; conditions commonly seen in the elderly as well as new findings which we felt were of great significance. Ultimately, we hope to update the reader on new cutaneous diagnostic tools of internal disease.