Performance of cystatin C-based equations in a pediatric cohort at high risk of kidney injury
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- 作者：Edward J. Nehus (1)
Benjamin L. Laskin (1) (2)
Thelma I. Kathman (1)
John J. Bissler (1) - 关键词：Cystatin C ; Glomerular filtration rate ; Transplant ; Oncology ; Pediatrics
- 刊名：Pediatric Nephrology
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：28
- 期：3
- 页码：453-461
- 全文大小：173KB
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47. Huang SH, Macnab JJ, Sontrop JM, Filler G, Gallo K, Lindsay RM, Clark WF (2011) Performance of the creatinine-based and the cystatin C-based glomerular filtration rate (GFR) estimating equations in a heterogenous sample of patients referred for nuclear GFR testing. Transl Res 157:357-67 lass="external" href="http://dx.doi.org/10.1016/j.trsl.2011.01.002">CrossRef - 作者单位：Edward J. Nehus (1)
Benjamin L. Laskin (1) (2)
Thelma I. Kathman (1)
John J. Bissler (1)
1. Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH, 45229-3039, USA
2. Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA - ISSN：1432-198X
文摘
Background Limited data exist on the performance of cystatin C-based glomerular filtration rate (GFR) equations in pediatric transplant recipients and other high-risk patients. The aim of our study was therefore to evaluate the performance of current cystatin C-based equations in this population. Methods This was a retrospective, cross-sectional study of 141 consecutive patients (58?% post-transplant) who received a nuclear medicine GFR (NucGFR) examination using 99mTc- diethylenetriaminepentaacetic acid at our institution. Subjects included children receiving liver, kidney or hematopoietic stem cell transplants and patients with oncologic or urologic disease. GFR estimates using published GFR estimating equations, including those based on cystatin C (Filler, Zappitelli, Larsson, Hoek, Rule and Le Bricon equations, respectively) and on both cystatin C and creatinine (Zappitelli, Bouvet and Schwartz equations, respectively), were evaluated and compared to the NucGFR measurement using Bland–Altman analysis. Results The mean NucGFR was 95 (interquartile range 76-11) ?ml/min/1.73?m2. Of the cystatin C-based equations, the Rule, Hoek, Zappitelli and Schwartz (2009 CKiD equation) formulas provided the closest agreement to the NucGFR estimate. All other formulas overestimated the GFR in our cohort. Conclusion Cystatin C-based GFR formulas can provide an accurate estimation of NucGFR in a pediatric population with a high proportion of transplant recipients and oncology patients.