Performance of cystatin C-based equations in a pediatric cohort at high risk of kidney injury

详细信息    查看全文

• 作者：Edward J. Nehus (1)
  Benjamin L. Laskin (1) (2)
  Thelma I. Kathman (1)
  John J. Bissler (1)
  
• 关键词：Cystatin C ; Glomerular filtration rate ; Transplant ; Oncology ; Pediatrics
• 刊名：Pediatric Nephrology
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：28
• 期：3
• 页码：453-461
• 全文大小：173KB
• 参考文献：1. Dharnidharka VR, Kwon C, Stevens G (2002) Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 40:221-26 CrossRef
  2. Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A (2005) Cystatin C as a marker of GFR—history, indications, and future research. Clin Biochem 38:1- CrossRef
  3. Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J (1998) Cystatin C–a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 101:875-81 CrossRef
  4. Filler G, Witt I, Priem F, Ehrich JH, Jung K (1997) Are cystatin C and beta 2-microglobulin better markers than serum creatinine for prediction of a normal glomerular filtration rate in pediatric subjects? Clin Chem 43:1077-078
  5. Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Brodehl J (1998) Reference values for cystatin C serum concentrations in children. Pediatr Nephrol 12:125-29 CrossRef
  6. Filler G, Lepage N (2003) Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 18:981-85 CrossRef
  7. Grubb A, Nyman U, Bjork J, Lindstrom V, Rippe B, Sterner G, Christensson A (2005) Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan–Barratt prediction equations for children. Clin Chem 51:1420-431 CrossRef
  8. Zappitelli M, Parvex P, Joseph L, Paradis G, Grey V, Lau S, Bell L (2006) Derivation and validation of cystatin C-based prediction equations for GFR in children. Am J Kidney Dis 48:221-30 CrossRef
  9. Filler G, Priem F, Vollmer I, Gellermann J, Jung K (1999) Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol 13:501-05 CrossRef
  10. Martini S, Prevot A, Mosig D, Werner D, van Melle G, Guignard JP (2003) Glomerular filtration rate: measure creatinine and height rather than cystatin C! Acta Paediatr 92:1052-057 CrossRef
  11. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629-37 CrossRef
  12. Balachandran S, Toguri AG, Petrusick TW, Abbott LC (1981) Comparative evaluation of quantitative glomerular filtration rate measured by isotopic and nonisotopic methods. Clin Nucl Med 6:150-53 CrossRef
  13. Brochner-Mortensen J, Haahr J, Christoffersen J (1974) A simple method for accurate assessment of the glomerular filtration rate in children. Scand J Clin Lab Invest 33:140-43
  14. Blaufox MD, Aurell M, Bubeck B, Fommei E, Piepsz A, Russell C, Taylor A, Thomsen HS, Volterrani D (1996) Report of the Radionuclides in Nephrourology Committee on renal clearance. J Nucl Med 37:1883-890
  15. Barbour GL, Crumb CK, Boyd CM, Reeves RD, Rastogi SP, Patterson RM (1976) Comparison of inulin, iothalamate, and 99mTc-DTPA for measurement of glomerular filtration rate. J Nucl Med 17:317-20
  16. Hoek FJ, Kemperman FA, Krediet RT (2003) A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant 18:2024-031 CrossRef
  17. Larsson A, Malm J, Grubb A, Hansson LO (2004) Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scand J Clin Lab Invest 64:25-0 CrossRef
  18. Le Bricon T, Thervet E, Froissart M, Benlakehal M, Bousquet B, Legendre C, Erlich D (2000) Plasma cystatin C is superior to 24-h creatinine clearance and plasma creatinine for estimation of glomerular filtration rate 3?months after kidney transplantation. Clin Chem 46:1206-207
  19. Rule AD, Bergstralh EJ, Slezak JM, Bergert J, Larson TS (2006) Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int 69:399-05 CrossRef
  20. Bouvet Y, Bouissou F, Coulais Y, Seronie-Vivien S, Tafani M, Decramer S, Chatelut E (2006) GFR is better estimated by considering both serum cystatin C and creatinine levels. Pediatr Nephrol 21:1299-306 CrossRef
  21. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307-10 CrossRef
  22. Perrone RD, Madias NE, Levey AS (1992) Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38:1933-953
  23. Samyn M, Cheeseman P, Bevis L, Taylor R, Samaroo B, Buxton-Thomas M, Heaton N, Rela M, Mieli-Vergani G, Dhawan A (2005) Cystatin C, an easy and reliable marker for assessment of renal dysfunction in children with liver disease and after liver transplantation. Liver Transpl 11:344-49 CrossRef
  24. Berding G, Geisler S, Melter M, Marquardt P, Luhr A, Scheller F, Knoop BO, Pfister ED, Pape L, Bischoff L, Knapp WH, Ehrich JH (2010) Estimation of glomerular filtration rate in liver-transplanted children: comparison of simplified procedures using 51Cr-EDTA and endogenous markers with Sapirstein’s method as a reference standard. Pediatr Transplant 14:786-95 CrossRef
  25. Blufpand HN, Tromp J, Abbink FC, Stoffel-Wagner B, Bouman AA, Schouten-van Meeteren AY, van Wijk JA, Kaspers GJ, Bokenkamp A (2011) Cystatin C more accurately detects mildly impaired renal function than creatinine in children receiving treatment for malignancy. Pediatr Blood Cancer 57:262-67 CrossRef
  26. Bacchetta J, Cochat P, Rognant N, Ranchin B, Hadj-Aissa A, Dubourg L (2011) Which creatinine and cystatin C equations can be reliably used in children? Clin J Am Soc Nephrol 6:552-60 CrossRef
  27. Mention K, Lahoche-Manucci A, Bonnevalle M, Pruvot FR, Declerck N, Foulard M, Gottrand F (2005) Renal function outcome in pediatric liver transplant recipients. Pediatr Transplant 9:201-07 CrossRef
  28. Borrows R, Cockwell P (2007) Measuring renal function in solid organ transplant recipients. Transplantation 83:529-31 CrossRef
  29. Takeuchi M, Fukuda Y, Nakano I, Katano Y, Hayakawa T (2001) Elevation of serum cystatin C concentrations in patients with chronic liver disease. Eur J Gastroenterol Hepatol 13:951-55 CrossRef
  30. Demirtas S, Akan O, Can M, Elmali E, Akan H (2006) Cystatin C can be affected by nonrenal factors: a preliminary study on leukemia. Clin Biochem 39:115-18 CrossRef
  31. Chu SC, Wang CP, Chang YH, Hsieh YS, Yang SF, Su JM, Yang CC, Chiou HL (2004) Increased cystatin C serum concentrations in patients with hepatic diseases of various severities. Clin Chim Acta 341:133-38 CrossRef
  32. Boudville N, Salama M, Jeffrey GP, Ferrari P (2009) The inaccuracy of cystatin C and creatinine-based equations in predicting GFR in orthotopic liver transplant recipients. Nephrol Dial Transplant 24:2926-930 CrossRef
  33. Chew JS, Saleem M, Florkowski CM, George PM (2009) Estimating renal function in oncology patients using cystatin C-based equations. Clin Oncol (R Coll Radiol) 21:425-26 CrossRef
  34. Gerhardt T, Poge U, Stoffel-Wagner B, Ahrendt M, Wolff M, Spengler U, Palmedo H, Sauerbruch T, Woitas RP (2006) Estimation of glomerular filtration rates after orthotopic liver transplantation: evaluation of cystatin C-based equations. Liver Transpl 12:1667-672 CrossRef
  35. Stake G, Monn E, Rootwelt K, Monclair T (1991) The clearance of iohexol as a measure of the glomerular filtration rate in children with chronic renal failure. Scand J Clin Lab Invest 51:729-34 CrossRef
  36. Houlihan C, Jenkins M, Osicka T, Scott A, Parkin D, Jerums G (1999) A comparison of the plasma disappearance of iohexol and 99mTc-DTPA for the measurement of glomerular filtration rate (GFR) in diabetes. Aust N Z J Med 29:693-00 CrossRef
  37. Schwartz GJ, Furth S, Cole SR, Warady B, Munoz A (2006) Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in children. Kidney Int 69:2070-077 CrossRef
  38. Ling Q, Xu X, Li J, Wu J, Chen J, Xie H, Zheng S (2008) A new serum cystatin C-based equation for assessing glomerular filtration rate in liver transplantation. Clin Chem Lab Med 46:405-10 CrossRef
  39. Risch L, Herklotz R, Blumberg A, Huber AR (2001) Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients. Clin Chem 47:2055-059
  40. Qutb A, Syed G, Tamim HM, Al Jondeby M, Jaradat M, Tamimi W, Al Ghamdi G, Al Qurashi S, Flaiw A, Hejaili F, Al Sayyari AA (2009) Cystatin C-based formula is superior to MDRD, Cockcroft–Gault and Nankivell formulae in estimating the glomerular filtration rate in renal allografts. Exp Clin Transpl 7:197-02
  41. White C, Akbari A, Hussain N, Dinh L, Filler G, Lepage N, Knoll GA (2007) Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equations. Nephrol Dial Transplant 22:3013-020 CrossRef
  42. White C, Akbari A, Hussain N, Dinh L, Filler G, Lepage N, Knoll GA (2005) Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods. J Am Soc Nephrol 16:3763-770 CrossRef
  43. Maillard N, Mariat C, Bonneau C, Mehdi M, Thibaudin L, Laporte S, Alamartine E, Chamson A, Berthoux F (2008) Cystatin C-based equations in renal transplantation: moving toward a better glomerular filtration rate prediction? Transplantation 85:1855-858 CrossRef
  44. Zahran A, Qureshi M, Shoker A (2007) Comparison between creatinine and cystatin C-based GFR equations in renal transplantation. Nephrol Dial Transplant 22:2659-668 CrossRef
  45. Poge U, Gerhardt T, Stoffel-Wagner B, Palmedo H, Klehr HU, Sauerbruch T, Woitas RP (2006) Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients. Kidney Int 70:204-10 CrossRef
  46. Poge U, Gerhardt T, Woitas RP (2008) Equations to estimate GFR using serum cystatin C in kidney transplant recipients. Am J Kidney Dis 52:383-84 CrossRef
  47. Huang SH, Macnab JJ, Sontrop JM, Filler G, Gallo K, Lindsay RM, Clark WF (2011) Performance of the creatinine-based and the cystatin C-based glomerular filtration rate (GFR) estimating equations in a heterogenous sample of patients referred for nuclear GFR testing. Transl Res 157:357-67 CrossRef
  
• 作者单位：Edward J. Nehus (1)
  Benjamin L. Laskin (1) (2)
  Thelma I. Kathman (1)
  John J. Bissler (1)
  
  1. Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH, 45229-3039, USA
  2. Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  
• ISSN：1432-198X

文摘

Background Limited data exist on the performance of cystatin C-based glomerular filtration rate (GFR) equations in pediatric transplant recipients and other high-risk patients. The aim of our study was therefore to evaluate the performance of current cystatin C-based equations in this population. Methods This was a retrospective, cross-sectional study of 141 consecutive patients (58?% post-transplant) who received a nuclear medicine GFR (NucGFR) examination using 99mTc- diethylenetriaminepentaacetic acid at our institution. Subjects included children receiving liver, kidney or hematopoietic stem cell transplants and patients with oncologic or urologic disease. GFR estimates using published GFR estimating equations, including those based on cystatin C (Filler, Zappitelli, Larsson, Hoek, Rule and Le Bricon equations, respectively) and on both cystatin C and creatinine (Zappitelli, Bouvet and Schwartz equations, respectively), were evaluated and compared to the NucGFR measurement using Bland–Altman analysis. Results The mean NucGFR was 95 (interquartile range 76-11) ?ml/min/1.73?m2. Of the cystatin C-based equations, the Rule, Hoek, Zappitelli and Schwartz (2009 CKiD equation) formulas provided the closest agreement to the NucGFR estimate. All other formulas overestimated the GFR in our cohort. Conclusion Cystatin C-based GFR formulas can provide an accurate estimation of NucGFR in a pediatric population with a high proportion of transplant recipients and oncology patients.