N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training

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• 作者：Catherine M. Jankowski (1) (2)
  Wendolyn S. Gozansky (2)
  Paul S. MacLean (3)
  Benjamin Shulman (4)
  Pamela Wolfe (4)
  Robert S. Schwartz (2)
  Wendy M. Kohrt (2)
  
• 关键词：Resistance exercise ; Acetaminophen ; Muscle hypertrophy ; Osteogenesis ; Mechanotransduction ; Lean tissue mass
• 刊名：European Journal of Applied Physiology
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：113
• 期：5
• 页码：1127-1136
• 全文大小：356KB
• 参考文献：1. American College of Sports Medicine (1998) Exercise and physical activity for older adults. Med Sci Sports Exerc 30:992-008 CrossRef
  2. American College of Sports Medicine (2010) ACSM’s Guidelines for Exercise Testing and Prescription, 8th edn. Lippincott Williams & Wilkins, Philadelphia
  3. Bondesen BA, Mills ST, Pavlath GK (2006) The COX-2 pathway regulates growth of atrophied muscles via multiple mechanisms. Am J Physiol Cell Physiol 290:C1651–C1659 CrossRef
  4. Chow JW, Chambers TJ (1994) Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am J Physiol 267:E287–E292
  5. Fry CS, Drummond MJ, Glynn EL, Dickinson JM, Gunderman DM, Timmerman KL, Walker DK, Dhanani S, Volpi E, Rasmussen BB (2011) Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet Muscle 1:1-1
  6. Graham GG, Scott KF (2005) Mechanism of action of paracetamol. Am J Ther 12:46-5 CrossRef
  7. Henderson GC, Dhatariya K, Ford GC, Klaus KA, Basu R, Rizza RA, Jensen MD, Khosla S, O’Brien P, Nair KS (2009) Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J 23:631-41 CrossRef
  8. Horsley V, Pavlath GK (2003) Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway. J Cell Biol 161:111-18 CrossRef
  9. Ito H, Ke HZ, Jee WS, Sakou T (1993) Anabolic responses of an adult cancellous bone site to prostaglandin E2 in the rat. Bone Miner 21:219-36 CrossRef
  10. Karamouzis M, Karamouzis I, Vamvakoudis E, Ampatzidis G, Christoulas K, Angelopoulou N, Mandroukas K (2001) The response of muscle interstitial prostaglandin E2 (PGE2), prostacycline I2 (PGI2) and thromboxane A2 (TXA2) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. Prostaglandins Leukot Essent Fatty Acids 64:259-63 CrossRef
  11. Kohrt WM, Barry DW, Van Pelt RE, Jankowski, Wolfe P, Schwartz RS (2010) Timing of ibuprofen use and bone mineral density adaptations to exercise training. J Bone Miner Res 25:1415-422
  12. Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling YR, American College of Sports Medicine (2004) American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 36:1985-996
  13. Lai J, Jin H, Yang R, Winer J, Li W, Yen R, King KL, Zeigler F, Ko A, Cheng J, Bunting S, Paoni NF (1996) Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo. Am J Physiol 271:H2197–H2208
  14. Li J, Burr DB, Turner CH (1997) Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading. Calcif Tissue Int 70:320-29 CrossRef
  15. Markworth JF, Cameron-Smith D (2011) Prostaglandin F_2α stimulates PI3K/ERK/mTOR signaling and skeletal myotube hypertrophy. Am J Physiol Cell Physiol 300:C671–C682 CrossRef
  16. Moldoveanu AI, Shephard RJ, Shek PN (2001) The cytokine response to physical activity and training. Sports Med 31:115-44 CrossRef
  17. Mundy GR (2007) Osteoporosis and inflammation. Nutr Rev 65:S147–S151 CrossRef
  18. Murray DW, Rushton N (1990) The effect of strain on bone cell prostaglandin E2 release: a new experimental method. Calcif Tissue Int 47:35-9 CrossRef
  19. O’Neill TK, Duffy LR, Frey JW, Hornberger TA (2009) The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contraction. J Physiol 587:3691-701 CrossRef
  20. Palmer RM (1990) Prostaglandins and the control of muscle protein synthesis and degradation. Prostaglandins Leukot Essent Fatty Acids 39:95-04 CrossRef
  21. Pead MJ, Lanyon LE (1989) Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tissue Int 45:34-0 CrossRef
  22. Rodemann HP, Goldberg AL (1982) Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. J Biol Chem 257:1632-638
  23. Sanaka M, Kuyama Y, Mineshita S, Qi J, Hanada Y, Enatsu I, Tanaka H, Makino H, Yamanaka M (1999) Pharmacokinetic interaction between acetaminophen and lansoprazole. J Clin Gastroenterol 29:56-8 CrossRef
  24. Schulte JN, Yarasheski KE (2001) Effects of resistance training on the rate of muscle protein synthesis in frail elderly people. Int J Sport Nutr Exerc Metab 11:S111–S118
  25. Somjen D, Binderman I, Berger E, Harell A (1980) Bone remodelling induced by physical stress is prostaglandin E2 mediated. Biochim Biophys Acta 627:91-00 CrossRef
  26. Tang LY, Cullen DM, Yee JA, Jee WS, Kimmel DB (1997) Prostaglandin E2 increases the skeletal response to mechanical loading. J Bone Miner Res 12:276-78
  27. Thoresen K, Kristoffersson AO, Lerner UH, Lorentzon RP (1996) In situ microdialysis in bone tissue. Stimulation of prostaglandin E2 release by weight-bearing mechanical loading. J Clin Invest 98:2446-449 CrossRef
  28. Trappe TA, Carroll CC, Dickinson JM, LeMoine JK, Haus JM, Sullivan BE, Lee JD, Jemiolo B, Weinheimer EM, Hollon CJ (2011) Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol Regul Integr Comp Physiol 300:R655–R662 CrossRef
  29. Trappe TA, Fluckey JD, White F, Lambert CP, Evans EM (2001) Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen and acetaminophen. J Clin Endocrinol Metab 86:5067-070 CrossRef
  30. Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans EM (2002) Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Endocrinol Metab 282:E551–E556
  31. Vandenburgh HH, Shansky J, Solerssi R, Chromiak J (1995) Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. J Cell Biol 163:285-94
  32. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:research0034.1–research0034.11
  33. Wu M, Katta A, Gadde MK, Liu H, Kakarla SK, Fannin J, Paturi S, Arvapalli RK, Rice KM, Wang Y, Blough ER (2009) Aging-associated dysfunction of Akt/protein kinase B: / S-nitrosylation and acetaminophen intervention. PLoS ONE 4:e6430 CrossRef
  
• 作者单位：Catherine M. Jankowski (1) (2)
  Wendolyn S. Gozansky (2)
  Paul S. MacLean (3)
  Benjamin Shulman (4)
  Pamela Wolfe (4)
  Robert S. Schwartz (2)
  Wendy M. Kohrt (2)
  
  1. College of Nursing, University of Colorado Anschutz Medical Campus, Mail Stop C288-19, 13120 East 19th Avenue, Aurora, CO, 80045-2527, USA
  2. Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA
  3. Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA
  4. Department of Preventive Medicine and Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA
  
• ISSN：1439-6327

文摘

N-acetyl-4-aminophenol (ACET) may impair musculoskeletal adaptations to progressive resistance exercise training (PRT) by inhibiting exercise-induced muscle protein synthesis and bone formation. To test the hypothesis that ACET would diminish training-induced increases in fat-free mass (FFM) and osteogenesis, untrained men (n?=?26) aged ?0?years participated in 16?weeks of high-intensity PRT and bone-loading exercises and were randomly assigned to take ACET (1,000?mg/day) or placebo (PLAC) 2?h before each exercise session. Total body FFM was measured by DXA at baseline and week 16. Serum bone-specific alkaline phosphatase (BAP) and C-terminal crosslinks of type-I collagen (CTX) were measured at baseline and week 16. Vastus lateralis muscle biopsies were performed at baseline and weeks 3 and 16 for prostanoid, anabolic, and catabolic gene expression by RT-PCR. In exercise-compliant men (ACET, n?=?10; PLAC, n?=?7), the increase in FFM was not different between groups (p?=?0.91). The changes in serum BAP and CTX were not different between groups (p?>?0.7). There were no significant changes in any of the target genes at week 3. After 16?weeks of PRT, the mRNA expressions of the anabolic marker p70S6K (p?=?0.003) and catabolic marker muscle-atrophy F-box (MAFbx) (p?=?0.03) were significantly reduced as compared to baseline in ACET. The mRNA expression of the prostanoids were unchanged (all p?≥?.40) in both groups. The administration of ACET (1,000?mg) prior to each exercise session did not impair PRT-induced increases in FFM or significantly alter bone formation markers in middle aged and older men.