Increased risk of lung cancer associated with occupational exposure to benzidine and/or beta-naphthylamine

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• 作者：Kimiko Tomioka ; Kenji Obayashi ; Keigo Saeki…
• 关键词：Aromatic amines ; Benzidine ; Beta ; naphthylamine ; Lung cancer ; Occupational exposure ; Cigarette smoking ; Historical cohort study
• 刊名：International Archives of Occupational and Environmental Health
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：88
• 期：4
• 页码：455-465
• 全文大小：240 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Occupational and Industrial Medicine
  Environmental Medicine/Environmental Psychology
  Rehabilitation
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1246

文摘

Purpose To evaluate non-urological cancer risks associated with benzidine (BZ) and beta-naphthylamine (BNA), a historical cohort study was undertaken. Methods A total of 224 male workers exposed to BZ/BNA from a single factory were followed from 1953 to 2011. To estimate BZ/BNA exposure dose, duration of exposure (DOE) was defined as duration of employment between 1953 and 1972, the period when BZ and BNA were produced and used at this factory. Subjects were dichotomized (into long- and short-term groups) based on the median of DOE. Cancer-specific standardized incidence ratios (SIRs) were calculated using national and regional incidence rates as reference. Smoking history was obtained through questionnaires and other sources. Association between lung cancer (LC) or bladder cancer (BC) incidence and DOE was assessed using Cox’s proportional hazards model. Results Vital status follow-up was successful for 216 (96.4?%). Follow-up duration averaged 44.0 (SD 10.7) years. Increased SIRs based on national rates were found for all cancers (81 cases, SIR?=?1.58, 95?% CI 1.26-.98), LC (18 cases, SIR?=?2.58, 95?% CI 1.53-.07), and BC (7 cases, SIR?=?4.70, 95?% CI 1.89-.67). Among workers with >20?years after first exposure, the SIR for LC was statistically elevated in the long DOE group (15 cases, SIR?=?3.34, 95?% CI 1.87-.51). After adjustment for smoking, exposure to bis(chloromethyl) ether, and age at first exposure, a marginally significant hazard ratio (HR) was observed for the long DOE group (adjusted HR?=?3.02, 95?% CI 0.84-0.93, p?=?0.091), compared to the short DOE group. DOE did not affect BC incidence. Conclusions This study confirms the high risk of LC besides BC, suggesting that BZ/BNA have the potential to cause LC.