Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms
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  • 作者:A. Ramesh ; P. A. Prins ; P. R. Perati…
  • 关键词:Benzo(a)pyrene ; Aortic aneurysms ; Atherosclerosis ; ApoE mouse ; Subcellular fractions
  • 刊名:Molecular and Cellular Biochemistry
  • 出版年:2016
  • 出版时间:January 2016
  • 年:2016
  • 卷:411
  • 期:1-2
  • 页码:383-391
  • 全文大小:931 KB
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  • 作者单位:A. Ramesh (1)
    P. A. Prins (2)
    P. R. Perati (2)
    P. V. Rekhadevi (1)
    U. K. Sampson (2) (3) (4)

    1. Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, USA
    2. Department of Medicine, Vanderbilt University Medical Center, Nashville, USA
    3. Departments of Pathology, Immunology, and Microbiology, Vanderbilt University Medical Center, Nashville, USA
    4. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, USA
  • 刊物类别:Biomedical and Life Sciences
  • 刊物主题:Life Sciences
    Biochemistry
    Medical Biochemistry
    Oncology
    Cardiology
  • 出版者:Springer Netherlands
  • ISSN:1573-4919
文摘
As exposure to polycyclic aromatic hydrocarbons (PAHs; a family of environmental toxicants) have been implicated in cardiovascular diseases, the ability of the aortic tissue to process these toxicants is important from the standpoint of abdominal aortic aneurysms and atherosclerosis. Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters. Therefore, knowledge of B(a)P metabolism in the cardiovascular system will be of importance in the management of vascular disorders. Toward this end, subcellular fractions (nuclear, cytosolic, mitochondrial, and microsomal) were isolated from the aortic tissues of Apo E mice that received a 5 mg/kg/week of B(a)P for 42 days and 0.71 mg/kg/day for 60 days. The fractions were incubated with 1 and 3 μM B(a)P. Post incubation, samples were extracted with ethyl acetate and analyzed by reverse-phase HPLC. Microsomal B(a)P metabolism was greater than the rest of the fractions. The B(a)P metabolite levels generated by all the subcellular fractions showed a B(a)P exposure concentration-dependent increase for both the weekly and daily B(a)P treatment categories. The preponderance of B(a)P metabolites such as 7,8-dihydrodiol, 3,6-, and 6,12-dione metabolites are interesting due to their reported involvement in B(a)P-induced toxicity through oxidative stress. Keywords Benzo(a)pyrene Aortic aneurysms Atherosclerosis ApoE mouse Subcellular fractions

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