Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study
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- 作者：Francesco Nicita ; Milena Paiano ; Mauro Liberatore ; Alberto Spalice…
- 关键词：Dentate ; thalamo ; cerebral pathway ; Posterior fossa surgery ; Cerebellar mutism ; Treatment ; Dopamine ; Akinetic mutism
- 刊名：Acta Neurochirurgica
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：159
- 期：3
- 页码：475-479
- 全文大小：
- 刊物主题：Neurosurgery; Interventional Radiology; Neuroradiology; Neurology; Surgical Orthopedics; Minimally Invasive Surgery;
- 出版者：Springer Vienna
- ISSN：0942-0940
- 卷排序：159
文摘
Post-operative pediatric cerebellar mutism syndrome (PPCMS) is a clinical syndrome arising from cerebellar injury and characterized by absence of speech and other possible symptoms and signs. Rare reports described some benefit after administration of dopamine agonist therapy, but no treatment has proven efficacy. In this paper, we report on the dramatic, sudden resolution of PPCMS induced by midazolam administration in a boy who underwent posterior fossa surgery for choroid plexus papilloma of the fourth ventricle. In addition to clinical improvement, post-midazolam single-photon emission computed tomography also demonstrated amelioration of brain perfusion.