Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis

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• 作者：Xue-jiao Gao ; Meng-yao Guo ; Ze-cai Zhang ; Tian-cheng Wang ; Yong-guo Cao…
• 关键词：bergenin ; mastitis ; anti ; inflammation ; nuclear factor ; kappaB (NF ; κB) ; mitogen ; activated protein kinases (MAPKs)
• 刊名：Inflammation
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：38
• 期：3
• 页码：1142-1150
• 全文大小：1,356 KB
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• 作者单位：Xue-jiao Gao (1)
  Meng-yao Guo (2)
  Ze-cai Zhang (1)
  Tian-cheng Wang (1)
  Yong-guo Cao (1)
  Nai-sheng Zhang (3)
  
  1. College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, 130062, People’s Republic of China
  2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China
  3. Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, 130062, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory and immunomodulatory properties. The objective of this study was to evaluate the protective effects and mechanism of bergenin on the mammary glands during lipopolysaccharide (LPS)-induced mastitis. In this study, mice were treated with LPS to induce mammary gland mastitis as a model for the disease. Bergenin treatment was initiated after LPS stimulation for 24?h. The results indicated that bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis. Furthermore, bergenin downregulated the phosphorylation of nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinases (MAPK) signaling pathway proteins in mammary glands with mastitis. In conclusion, bergenin reduced the expression of NO, TNF-α, IL-1β, and IL-6 proinflammatory cytokines by inhibiting the activation of the NF-κB and MAPKs signaling pathways, and it may represent a novel treatment strategy for mastitis.