Rationale and design of a randomized, controlled multicentre clinical trial to evaluate the effect of bromocriptine on left ventricular function in women with peripartum cardiomyopathy
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- 作者：Arash Haghikia ; Edith Podewski ; Dominik Berliner…
- 关键词：Peripartum cardiomyopathy ; Bromocriptine ; Prolactin ; Heart failure
- 刊名：Clinical Research in Cardiology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：104
- 期：11
- 页码：911-917
- 全文大小：447 KB
- 刊物主题：Cardiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1861-0692
文摘
Background Peripartum cardiomyopathy (PPCM) is an idiopathic heart disease that develops in the last month of pregnancy and/or the first months following delivery in previously healthy women and may lead to acute heart failure. A cleaved fragment of the nursing hormone prolactin is considered essential in the pathophysiology of PPCM. To date, no specific therapy has been tested for PPCM in a randomized controlled trial of adequate size.