Neuronal Nitric Oxide Synthase Immunopositivity in Motoneurons of the Rabbit's Spinal Cord After Transient Ischemia/Reperfusion Injury

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• 作者：A. Schreiberová ; M. Lacková ; D. Kolesár ; N. Luká?ová and J. Mar?ala
• 关键词：KEY WORDS ; ischemia/reperfusion ; ventral horn ; motoneurons ; neuronal nitric oxide synthase ; rabbit
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2006
• 出版时间：November, 2006
• 年：2006
• 卷：26
• 期：7-8
• 页码：1481-1492
• 全文大小：433 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

1. Motoneurons in the spinal cord are especially vulnerable to ischemic injury and selectively destroyed after transient ischemia. To evaluate the role of nitric oxide (NO) in the pathophysiology of the spinal cord ischemia, the expression of neuronal nitric oxide synthase (nNOS) in the motoneurons of the lumbosacral spinal cord was examined in the rabbit model of transient abdominal aorta occlusion.2. The aim of the present study was to find if there is any consensus between the duration of transient abdominal aorta occlusion, nNOS positivity of the motoneurons and neurological hind limb impairment.