Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats

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• 作者：Jeffery D. Steketee and Chad E. Beyer
• 关键词：Baclofen ; Cocaine ; GABA ; Motor activity ; Sensitization
• 刊名：Psychopharmacology
• 出版年：2005
• 出版时间：July 2005
• 年：2005
• 卷：180
• 期：2
• 页码：352-358
• 全文大小：211 KB

文摘

Rationale Increased excitatory output from the medial prefrontal cortex (mPFC) is thought to play a key role in the development of sensitization to cocaine. Gamma-aminobutyric acid (GABA) inhibits this excitatory output.