Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models
详细信息 查看全文
- 作者：Jason M. Dwyer ; Stacey J. Sukoff Rizzo ; Sarah J. Neal ; Qian Lin ; Flora Jow ; Robert L. Arias ; Sharon Rosenzweig-Lipson ; John Dunlop and Chad E. Beyer
- 关键词：Anxiety ; Anxiolytic ; Acid ; Channel ; Stress ; Autonomic ; Benzodiazepine ; Mice ; Microdialysis ; GABA
- 刊名：Psychopharmacology
- 出版年：2009
- 出版时间：March, 2009
- 年：2009
- 卷：203
- 期：1
- 页码：41-52
- 全文大小：606.7 KB
文摘
Rationale Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and anxiety.