The CRHR1 Gene Contributes to Genetic Susceptibility of Aggressive Behavior Towards Others in Chinese Southwest Han Population

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• 作者：Bifeng Chen (1)
  Tao Gu (2)
  Bo Ma (3)
  Guoqing Zheng (4)
  Bingxiong Ke (4)
  Xiufeng Zhang (5)
  Lirui Zhang (5)
  Yuanyuan Wang (6)
  Liping Hu (5)
  Yang Chen (5)
  Jianbo Qiu (7)
  Shengjie Nie (5)
  
• 关键词：Aggressive behavior ; CRHR1 ; SNP ; Haplotype ; HPA axis ; Han population
• 刊名：Journal of Molecular Neuroscience
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：52
• 期：4
• 页码：481-486
• 全文大小：152 KB
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• 作者单位：Bifeng Chen (1)
  Tao Gu (2)
  Bo Ma (3)
  Guoqing Zheng (4)
  Bingxiong Ke (4)
  Xiufeng Zhang (5)
  Lirui Zhang (5)
  Yuanyuan Wang (6)
  Liping Hu (5)
  Yang Chen (5)
  Jianbo Qiu (7)
  Shengjie Nie (5)
  
  1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
  2. Center for Disease Prevention and Control of Kunming, Kunming, Yunnan, 650228, China
  3. Yunnan Walvax Biotechnology Co., Ltd, Kunming, Yunnan, 650106, China
  4. Yunnan Guandu Prison, Kunming, Yunnan, 650211, China
  5. School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, China
  6. First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, 650500, China
  7. Criminal Investigation Squadrons of Nanjian Police Bureau, Dali, Yunnan, 675700, China
  
• ISSN：1559-1166

文摘

Accumulating evidence suggests that the hypothalamic–pituitary–adrenal (HPA) axis might play a major role in genetic susceptibility of aggressive behavior. The aim of the present study is to investigate the association between corticotrophin-releasing hormone receptor 1 (CRHR1) gene and aggressive behavior in Chinese southwest Han population. Participants consist of 282 healthy controls and 177 violent criminals (including robbery and intentional injury, which represent for aggressive behavior towards property and aggressive behavior towards others). Three tag single nucleotide polymorphisms (SNPs) of CRHR1 gene including rs4458044, rs242924, and rs1768996 were genotyped using improved multiplex ligase detection reaction (iMLDR) methods. Single-locus analysis revealed that none of the studied SNPs was significantly associated with the risk of aggressive behavior; however, haplotype analysis showed that a haplotype GGA significantly increased the susceptibility of aggressive behavior towards others with an odds ratios equal to 3.32 (p--.003). The present results, for the first time, indicate that the CRHR1 gene polymorphism is significantly associated with aggressive behavior in Chinese southwest Han population. Subjects with GGA haplotype have an increased susceptibility to aggressive behavior towards others.