Serum VEGF and VEGF-C values before surgery and after postoperative treatment in gastric cancer

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• 作者：Pedro Villarejo-Campos (1)
  David Padilla-Valverde (1)
  Raúl Martin Martin (2)
  Pablo Menéndez-Sánchez (1)
  Teófilo Cubo-Cintas (1)
  Jose Antonio Bondia-Navarro (3)
  Jesús Martín Fernández (1)
  
• 关键词：Gastric cancer ; Serum VEGF ; Serum VEGF ; C ; Angiogenesis ; Lymphangiogenesis ; Lymph node metastasis ; Survival
• 刊名：Clinical and Translational Oncology
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：15
• 期：4
• 页码：265-270
• 全文大小：244KB
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• 作者单位：Pedro Villarejo-Campos (1)
  David Padilla-Valverde (1)
  Raúl Martin Martin (2)
  Pablo Menéndez-Sánchez (1)
  Teófilo Cubo-Cintas (1)
  Jose Antonio Bondia-Navarro (3)
  Jesús Martín Fernández (1)
  
  1. Hospital Universitario de Ciudad Real, Carretera Piedrabuena, 20/26-A, Ciudad Real, 13005, Spain
  2. área de Estadística e Innovación Operativa. Departamento de Matemáticas, Universidad de Castilla-La Mancha, Castilla La Mancha, Spain
  3. Facultad de Medicina, Universidad de Málaga, Málaga, Spain
  

文摘

Introduction Angiogenesis and lymphangiogenesis are essential processes for the formation of blood and lymphatic vessels that allow tumour growth and spread. The binding of VEGF and VEGF-C factors with their receptors (VEGFR2, VEGFR3) in endothelial cells triggers signals that regulate these processes. We compared preoperative serum VEGF and VEGF-C levels with samples obtained after completion of surgery and adjuvant treatment in patients with gastric cancer. In addition, we determined the prognostic value and relationship to survival of serum VEGF and VEGF-C levels. Methods We used a prospective cohort study of 59 gastric cancer patients who underwent surgery. Serum VEGF and VEGF-C were measured by enzyme-linked immunosorbent assay (ELISA) the day before surgery and 6?months later, after completion of adjuvant treatment. Results Serum VEGF values decreased after treatment in patients with resectable tumours (mean?±?SD) (405.42?±?298.38 vs. 306.38?±?212.47?pg/ml; p?<?0.01), poorly differentiated and undifferentiated tumours (G3, G4) (438?±?339.71 vs. 322.47?±?210.71?pg/ml; p?=?0.01), locally advanced gastric tumours (T4 stage) (424.27?±?323.08 vs. 333.62?±?221.72?pg/ml; p?=?0.03) and tumours with a greater number of involved regional lymph nodes (N3) (442.38?±?311.52 vs. 337.4?±?203.64?pg/ml; p?=?0.04). Serum preoperative VEGF values over 761?pg/ml were associated with shorter patient survival. The mean overall survival time for patients with serum VEGF levels higher than 761?pg/ml was 7?±?2.99?months (95?% CI 1.14-2.86) while for patients with serum VEGF levels of less than 761?pg/ml was 21.18?±?2.88 (95?% CI 15.54-6.83) The mean disease-specific survival time for patients with serum VEGF levels higher than 761?pg/ml was 6.25?±?2.53?months (95?% CI 1.29-1.21) while for patients with serum VEGF levels of less than 761?pg/ml was 27.57?±?3.45 (95?% CI 20.80-4.35). Multivariate analysis identified preoperative serum VEGF levels as an independent prognostic factor (HR?=?0.144; p?=?0.03). Conclusions Serum VEGF levels decreased after the completion of treatment in patients with resected tumours, suggesting VEGF tracking may be useful in monitoring progression. Preoperative measurement of serum VEGF may help us identify patients with a poor prognosis.