Structural Characterizations of the Fas Receptor and the Fas-Associated Protein with Death Domain Interactions

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• 作者：Urmi Roy
• 关键词：Death domain ; Fas ; associated protein with death domain ; Fas ; Immunology ; Structural biology
• 刊名：The Protein Journal
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：35
• 期：1
• 页码：51-60
• 全文大小：2,033 KB
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• 作者单位：Urmi Roy (1)
  
  1. Department of Chemistry and Biomolecular Science, and Center for Advanced Materials Processing, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5665, USA
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Bioorganic Chemistry
  Biochemistry
  Organic Chemistry
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-4943

文摘

The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor’s activity. The Fas–FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems. The interactions responsible for this cell-death process are governed by the binding process of the Fas ligand to the Fas, followed by the caspase cascade activation. Using a computational approach, the present communication explores certain essential structural aspects of the Fas–FADD death domains and their interfacial interactions. Keywords Death domain Fas-associated protein with death domain Fas Immunology Structural biology